地佐辛与芬太尼用于儿童咽成形术后镇痛比较  

The comparison of postoperative analgesia of dezocine and fentanyl in children undergoing pharyngoplasty surgery

作　　者：曹静[1] 张晓彤[1] 扈大为[1] 朱雯竞[1] 

机构地区：[1]首都医科大学口腔医学院麻醉科,北京100050

出　　处：《北京口腔医学》2016年第4期219-221,共3页Beijing Journal of Stomatology

摘　　要：目的 探讨地佐辛与芬太尼用于儿童咽成形术后静脉自控镇痛（PICA）的安全性和有效性。方法选择59例择期咽成形手术患者，随机分为芬太尼组（31例）和地佐辛组（28例），术后分别用芬太尼和地佐辛行静脉自控镇痛，并在术后1、3、6、12、24h观测患者的镇痛及镇静效果。结果两组患者均取得良好镇痛效果，各时点比较差异没有统计学意义（P〉0．05）。术后1h镇静评分芬太尼组高于地佐辛组，且有镇静过度发生（P〈0．05），其余各时间点2组比较差异无统计学意义（P〉0．05）。术后1—3h平均动脉压、心率和血氧饱和度芬太尼组低于地佐辛组（P〈0．05），术后不良反应呼吸抑制、恶心呕吐的发生率芬太尼组高于地佐辛组。结论地佐辛用于咽成形术患者静脉自控镇痛优于芬太尼，效果确切安全。Objective To evaluate the safety and efficiency of dezocine and fentanyl in childer＇ s self-control vein analgesia（ PICA ） after pharyngoplasty surgery. Methods Fifty-nine patients undergoing pharyngoplasty surgery were randomly divided into the fentanyl group （ n = 31 ） and the dezocine group （ n = 28 ）. The postoperative analgesia and sedation were assessed lh, 3h, 6h, 12h, 24 h after surgery. Results Good analgesic and sedative effect was achieved in the two groups and the difference was not significant （P 〉 O. 05）. The sedation effect of fentanyl group was better than that of dezocine group at 1 h （ P 〈 0.05 ）, but the sedation was excessive. There was no significant difference at other time points between the two groups （P 〉 O. 05 ）. The mean arterial pressure, heart rate and blood oxygen saturation in fentanyl group were lower than those in dezocine group （P 〈 0.05 ） , and the incidence of nausea and vomiting and the respiratory depression in fentanyl group were higher than that in dezocine group. Conclusion Fentanyl and dezocine can provide an efficient analgesia and sedation. Self-control vein analgesia with dezocine is safer after pharyngoplasty surgery.

关 键 词：地佐辛 芬太尼 咽成型术 术后镇痛 

分 类 号：R782.054[医药卫生—口腔医学]