乳腺癌组织IGFBP7表达及其临床意义的研究  

Study on the expression of IGFBP7 in patients with breast cancer and its clinical significance

作　　者：李伯和[1] 袁磊[1] 游颜杰[2] 马培栋[3] 

机构地区：[1]漯河医学高等专科学校分子医学实验室,河南漯河462002 [2]漯河医学高等专科学校病理学教研室,河南漯河462002 [3]漯河医学高等专科学校第一附属医院乳腺外科,河南漯河462002

出　　处：《重庆医学》2016年第24期3358-3360,共3页Chongqing medicine

基　　金：河南省科技厅科技发展计划项目(142102310466);漯河医学高等专科学校科研基金资助项目(2014-S-LMC09)

摘　　要：目的探究胰岛素样生长因子结合蛋白7(IGFBP7)的表达与乳腺癌临床病理因素及预后的相关性。方法采用免疫组织化学法检测105例乳腺癌患者IGFBP7的表达,并分析IGFBP7的表达情况与乳腺癌患者临床病理特征之间的关系,采用Kaplan-Meier法分析乳腺癌患者的5年无瘤生存率。结果 105例乳腺癌患者癌组织中IGFBP7阳性率为57.1%;IGFBP7表达水平与组织学分级、肿瘤大小、淋巴结转移、雌激素受体表达和孕激素受体表达有明显相关性(P<0.05),但与年龄、绝经状态、TNM分期、病理类型和人类表皮生长因子受体2(HER-2)表达无相关性(P>0.05)。IGFBP7阳性患者的5年无病生存率显著高于IGFBP7阴性患者(P<0.05)。多因素Cox回归模型分析结果表明,IGFBP7表达和淋巴结转移是影响乳腺癌患者生存期的独立因素(P<0.05)。结论 IGFBP7表达阳性的乳腺癌患者更易复发转移。Objective To investigate the relationship between insulin-like growth factor binding protein 7（IGFBP7） and clin- ical factors and prognosis of breast cancer. Methods A total of 105 cases of breast cancer were detected for the expression of IG- FBP7 by the immunohistochemical method, and the relationship between the expression of IGFBP7 and clinical factors was ana- lyzed. The 5-year disease-free survival（DSF） was analyzed by Kaplan-Meier method. Results The expression of IGFBP7 was detec- ted in 5.7.1% of breast cancer cases. In the 105 cases of breast cancer patients,the expression of IGFBP7 was correlated with patho- logical grade, tumor size,lymph node metastasis, expression of estrogen receptor（ER） and progestrone receptor（PR）, with statisti- cal difference（P〈0.05）. However,it did not show any correlation with age, menopausal status, TNM stage, pathologic types and the expression of HER-2（P〉0. 05）. The 5-year DSF of IGFBP7 negative patients was markedly lower than that of IGFBP7 positive patients（P〈0.05）. Cox multivariate analysis indicated that the expression of IGFBP7 and lymph node metastasis were the inde- pendent prognostic factors affecting survival rate of breast cancer patients（P〈0. 05）. Conclusion The IGFBP7 positive patients with breast cancer may be more prone to recurrence and metastasis.

关 键 词：乳腺肿瘤 胰岛素样生长因子结合蛋白7 免疫组织化学 生存分析 

分 类 号：R737.9[医药卫生—肿瘤]