上皮型钙黏蛋白1及MutL同源基因1在甲状腺癌中的表达及意义  

The Clinical Significance of CDH1 and MLH1 Expression in Thyroid Carcinomas

作　　者：陈玉涛[1] 王五俊[1] 张鹏[2] 

机构地区：[1]天津市北辰医院外科,天津300400 [2]天津医科大学总医院普外科,天津300070

出　　处：《中国中西医结合外科杂志》2016年第4期328-331,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:探讨上皮型钙黏蛋白1(CDH1)及MutL同源基因1(MLH1)在甲状腺癌中的表达及与临床病理特征的关系。方法:分析手术治疗且资料完整的61例甲状腺癌患者的临床资料,采用免疫组化法检测甲状腺癌组织及癌旁组织中CDH1及MLH1蛋白的表达情况,并与其临床病理学资料进行比较。结果:CDH1和MLH1在甲状腺癌组织、癌旁组织中的阳性率分别为40.98%(25/61),81.97(50/61)和54.10(33/61),86.89%(53/61),CDH1及MLH1在癌组织中的表达率均显著低于癌旁组织(P<0.05);甲状腺癌组织中CDH1的阳性表达与淋巴结转移及肿瘤分期有关(P<0.05),而MLH1的表达与淋巴结转移有关(P<0.05)。结论:CDH1和MLH1蛋白可能与甲状腺癌的发生发展有关,并可作为甲状腺癌淋巴结转移的标志物。Objective To investigate the CDH1 and MLH1 expression in thyroid carcinoma and their association with the clincial pathological characteristics. Methods Sixty-one thyroid carcinomas that received surger with complete clinical data were included in this study. The cancer tissue （n=61） and para-cancer tissue were examined for CDH1 and MLH1 expression by immunohistochemical method. The correlation between CDH1 and MLH1 expression in thyroid carcinomas and clincial pathology characteristics were evaluated. Results The positive rate of CDH1 in cancer tissue and para-cancer tissue were 40.98%（25/61） and 81.97%（50/61）. But for MLH1, 54.10%（33/61） in cancer tissues and 86.89%（53/61） in para-cancer tissues. CDH1 positive expression in cancer tissue was correlated with lymph node metastasis （P〈0.05）, clinical stage （P〈0.05）, but MLH1 was not correlated with lymph node metastasis（P〉0.05）. Conclusion CDH1 and MLH1 protein may be related to the occurrence and development of thyroid carcinoma, which can be used as a marker of lymph node metastasis of thyroid carcinoma.

关 键 词：甲状腺癌 上皮型钙黏着蛋白1 MutL同源基因1 表达水平 临床病理特征 

分 类 号：R736.1[医药卫生—肿瘤]