长期肠内营养治疗患者合并用药与腹泻的相关性分析  

Analysis on correlation between combined medication and diarrhea in patients with long-term enteral nutrition

作　　者：龙晓静[1] 刘菁[2] 曾英[1] 江涛[1] 张露艺[1] 陈冬梅[1] 

机构地区：[1]广西中医药大学第一附属医院营养科,广西南宁530023 [2]新疆维吾尔自治区人民医院临床营养研究所,新疆乌鲁木齐830000

出　　处：《现代医药卫生》2016年第16期2469-2471,共3页Journal of Modern Medicine & Health

摘　　要：目的分析肠内营养治疗患者合并用药与腹泻发生的关系。方法采用回顾性病例分析方法 ,选择广西中医药大学第一附属医院2014年10月至2015年10月行肠内营养支持治疗的住院患者263例,记录肠内营养制剂及合并用药的使用情况。按是否发生腹泻将患者分为腹泻组(116例)和对照组(147例)。对两组患者肠内营养制剂种类、合并用药情况情况进行分析。结果腹泻组的胃动力药、钾制剂、抑酸药使用率分别为50.9%、40.5%、70.7%,高于对照组的32.0%、19.7%、24.5%,差异均有统计学意义(P<0.01)。腹泻组谷氨酰胺、益生菌制剂、膳食纤维使用率分别为27.6%、35.3%、28.4%,低于对照组的43.5%、69.4%、40.8%,差异均有统计学意义(P<0.05或0.01)。腹泻组同时使用2种以上药物占72.4%(84/116),高于对照组的54.4%(80/147),差异有统计学意义(P<0.05)。结论合并用药是肠内营养相关性腹泻的影响因素,进行肠内营养治疗应优化处方,尽可能少用或不用易导致腹泻的制剂。Objective To study the relationship between combined medication and diarrhea occurrence in the patients with enteral nutrition. Methods Totally 263 inpatients with enteral nutrition support in our hospital from October 2014 to October2015 were selected by adopting the retrospective case analysis. The use situation of enteral nutrition preparations and combined medication were recorded. The patients were divided into the diarrhea group（116 cases） and control group（147 cases） according to whether diarrhea occurring. The enteral nutrition preparations kinds and combined medication in the two groups were analyzed.Results The use rates of the gastric motor drugs,potassium preparations and antacid agents in the diarrhea group were 50.9%,40.5% and 70.7% respectively,which were respectively higher than 32.0%,19.7% and 24.5% in the control group,the differences had statistical significance（P〈0.01）. The use rates of glutamine,probiotic preparations and dietary fiber in the diarrhea group were27.6%,35.3% and 28.4% respectively,which were respectively lower than 43.5%,69.4% and 40.8% in the control group,the differences had statistical significance（P〈0.05 or 0.01）. The simultaneous use of 2 drugs or more in the diarrhea group accounted for72.4%（84/116）,which was higher than 54.4%（80/147） in the control group,the difference was statistically significant（P〈0.05）.Conclusion The combined medication is a influencing factor in enteral nutrition related diarrhea. Conducting the enteral nutri-tion should optimize the prescription,and using the preparations easier to cause diarrhea should be reduced to minimal level or avoided as much as possible.

关 键 词：肠道营养 腹泻 胃肠病用药 

分 类 号：R735.1[医药卫生—肿瘤]