帕金森病患者血浆肿瘤坏死因子-α和白介素-6与非运动症状的相关性分析  

Correlation analysis between tumor necrosis factor-a,interleukin-6 and non-motor symptoms in patients with Parkinson's disease

作　　者：王剑锋[1] 陈思[1] 王玲玲[1] 马俊[1] 岳涛[2] 姚小美[3] 赵振向 王晓棠[1] 刘艺鸣[1] 

机构地区：[1]山东大学齐鲁医院神经内科,济南250012 [2]淄博市中心医院干部保健科 [3]济南市中心医院干部保健科

出　　处：《临床神经病学杂志》2016年第4期299-301,共3页Journal of Clinical Neurology

基　　金：山东省科技攻关项目(2014GSF118024)

摘　　要：目的探讨帕金森病(PD)患者血浆TNF-α和IL-6水平与非运动症状的相关性。方法采用ELISA法测定41例原发性PD患者(PD组)和37名健康对照者(正常对照组)血浆TNF-α和IL-6的水平。采用Hoehn-Yahr分期(H-Y分期)、统一PD评定量表第Ⅱ部分(UPDRSⅡ)、统一PD评定量表第Ⅲ部分(UPDRSⅢ)、非运动症状量表(NMSS)评价PD患者关期时的运动和非运动症状。结果与正常对照组比较,PD组TNF-α和IL-6水平显著降低(均P<0.05)。PD组TNF-α水平与H-Y分期、UPDRSⅡ、UPDRSⅢ和NMSS评分无相关性(r=0.093,P=0.562;r=-0.024,P=0.882;r=0.131,P=0.415;r=-0.109,P=0.499)。PD组IL-6水平与H-Y分期、UPDRSⅡ、NMSS评分呈显著负相关(r=-0.411,P=0.008;r=-0.321,P=0.041;r=-0.324,P=0.039),与UPDRSⅢ评分无相关性(r=-0.126,P=0.431)。结论 PD患者可能存在免疫功能异常,且免疫炎症机制的异常可能参与PD非运动症状的致病过程。Objective To explore the correlation between plasma TNF-α,IL-6 levels and non-motor symptoms in patients with Parkinson＇s disease（ PD）. Methods The levels of plasma TNF-α and IL-6 of 41 PD patients（ PD group） and 37 healthy controls（ normal control group） were tested by ELISA. All PD patients were evaluated during＂off＂medication state,motor and non-motor symptoms were assessed by Hoehn-Yahr stage（ H-Y stage）,Unified Parkinson Disease Rating ScaleⅡ（ UPDRS Ⅱ） and Unified Parkinson Disease Rating Scale Ⅲ（ UPDRS Ⅲ） and non-motor symptoms scales（ NMSS）. Results Compared with PD group,IL-6 and TNF-α levels were significantly decreased（ all P 0. 05）. There was no correlation between TNF-α level and H-Y stage,UPDRS Ⅱ,UPDRS Ⅲ,NMSS scores in PD group（ r = 0. 093,P = 0. 562; r =- 0. 024,P = 0. 882; r = 0. 131,P = 0. 415; r =- 0. 109,P = 0. 499）. There was a negative correlation between IL-6 level and H-Y stage,UPDRS Ⅱ,NMSS scores in PD group（ r =- 0. 411,P = 0. 008; r =- 0. 321,P = 0. 041; r =- 0. 324,P = 0. 039）,and there was no correlation between IL-6 level and UPDRS Ⅲ score in PD group（ r =- 0. 126,P = 0. 431）. Conclusion PD patients may undergo immunological abnormalities,which may involve in the pathogenesis of non-motor symptoms of PD.

关 键 词：帕金森病 TNF-Α IL-6 非运动症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]