转基因治疗不孕相关疾病研究进展  

Research progress of gene transfer therapy for infertility

作　　者：谢诗[1] 赵静[1] 李艳萍[1] 

机构地区：[1]中南大学湘雅医院妇产科生殖医学中心,长沙410008

出　　处：《生殖与避孕》2016年第8期678-682,共5页Reproduction and Contraception

摘　　要：转基因治疗可以在一定程度上纠正或补偿基因异常或缺陷所导致的不孕相关疾病,以使部分患者获得生育能力。但现阶段转基因治疗仍处于初始阶段,应用范围有限,并且其体内研究均使用的动物模型,因涉及到伦理及潜在的安全问题限制了其在人体的直接应用。本综述分别从女性不孕、男性不育两方面对转基因治疗的研究进展进行总结,为今后不孕相关疾病的治疗提供了一个新的思路。Gene transfer therapy can treat some infertile diseases by correcting or compensating genetic abnormalities or defects to some extent. However, gene transfer therapy is still in the initial stage at present. Because of the ethics and potential safety problems involved, gene transfer therapy has not been widely applied, especially directly applied to the human body. All of the researches in vivo used animal models. The current review summarizes the research progress of gene transfer therapy in female and male infertility respectively, and provides a new thought for the future of infertility treatment.

关 键 词：不育 基因异常 转基因治疗 

分 类 号：R711.6[医药卫生—妇产科学]