孤雌胚胎干细胞在细胞疗法中的优势与局限性  

Advantages and limitations of parthenogenetic embryonic stem cells in cell therapy

作　　者：余朝阳 韩宝生[2] 

机构地区：[1]华北理工大学,唐山063000 [2]河北省唐山市妇幼保健院生殖遗传中心,唐山063000

出　　处：《生殖与避孕》2016年第8期683-689,共7页Reproduction and Contraception

摘　　要：孤雌胚胎干细胞(p ESCs)是建立患者特异性多能干细胞的有效途径,因具有类似胚胎干细胞(ESCs)自我复制和多潜能特性,成为再生医学的"种子细胞"。杂合型p ESCs有望用于自体移植,纯合型p ESCs理论上可用于异体基因疗法,却因自然杀伤(NK)细胞识别而产生免疫排斥反应。本文旨在综述孤雌生殖的表观遗传特性,总结p ESCs在细胞疗法中的优势和局限性,阐述克服免疫排斥反应的新策略。Parthenogenetic embryonic stem cells （pESCs）, as ＂seed cells＂ for regenerative medicine, are an effective way to build specific pluripotent stem cells for patients, because of its similarity of self-renewal and pluripotent characteristics to embryonic stem cells （ESCs）. Heterozygous pESCs is expected to be used for autologous transplantation, while homozygous pESCs can be used for allogeneic gene therapy in theory. In the paper, we review parthenogenesis epigenetic characteristics, and summarize the advantages and limitations of pESCs in the area of cell therapy, and elaborate the latest strategies of overcoming immune rejection.

关 键 词：孤雌胚胎干细胞(pESCs) 基因组印记 细胞疗法 纯合型 杂合型 

分 类 号：R456[医药卫生—治疗学]