45d-6°头低位卧床对下肢肌萎缩的影响及中药红景天的作用  

Effects of 45 d-6° Head-down Bed Rest on Lower Limb Muscle Atrophy and Interferences of Traditional Chinese Medicine Rhodiola Rosea

作　　者：李景龙[1,2] 刘红菊[2] 张鹏[2] 贺健[2] 李文炯[2] 王飞[2] 任维[1] 陈善广[3] 陈晓萍[2,3] 

机构地区：[1]陕西师范大学生命科学院,陕西西安710119 [2]中国航天员科研训练中心航天医学基础与应用国家重点实验室,北京100094 [3]中国航天员科研训练中心人因工程重点实验室,北京100094

出　　处：《航天医学与医学工程》2016年第4期256-259,共4页Space Medicine & Medical Engineering

基　　金：国家重大基础研究973计划项目(2011CB711000);人因工程重点实验室基金项目(SYFD140051801)

摘　　要：目的观察模拟失重效应对下肢肌萎缩的影响及中药红景天的干预作用。方法 16名成年男性健康志愿者随机分为对照组(8人)和用药组(8人),进行45 d-6°头低位卧床模拟长期失重效应实验。卧床期间,用药组和对照组每天分别服用红景天(红益胶囊)和安慰剂。卧床前、中、后动态测量小腿围径;并采用MRI技术,测试和分析卧床前、后大腿和小腿肌群最大横截面积和肌肉体积的变化。结果1)卧床期间用药组和对照组小腿围径进行性下降,在卧床30和45 d均显著下降(P<0.01),但用药组下降幅度显著减少(P<0.05);2)卧床45 d,用药组和对照组大腿和小腿肌肉最大横截面积均显著降低(P<0.01),其中小腿比目鱼肌下降幅度最大。用药组肌肉最大横截面积的减少较对照组均有改善作用(P<0.05);3)对照组大腿和小腿肌群肌肉体积在卧床45 d均显著下降(P<0.01),以比目鱼肌体积下降最为明显,用药组下降幅度显著减少,且比目鱼肌对抗作用最为明显(P<0.01)。结论 45 d-6°头低位卧床引起进行性加重的肌萎缩,中药红景天可部分对抗模拟长期失重效应诱导的下肢肌萎缩。Objective To investigate the effects of simulated weightlessness on lower limb skeletal muscle atrophy and influences of the Chinese traditional medicine rhodiola rosea on them. Methods Sixteen healthy adult male volunteers participated in the experiment of 45 d- 6°head-down bed rest（ HDBR） and were divided into two groups randomly. During HDBR,treatment group（ n = 8） took rhodiola rosea（ Hongyi capsules） and control group（ n = 8） took placebo capsules every day. Leg circumference was detected,and the maximal cross section area（ CSA） and volume of thigh and leg muscle groups were determined with MRI analysis before and after HDBR. Results 1） During HDBR,the average leg circumference of the two groups progressively decreased and were significantly declined on the 30 th and 45 th day（ P〈0. 01）,however,in treatment group the reduced extent of leg circumference was attenuated（ P〈0. 05） as compared with control group; 2） On the45 th day,although the maximal CSA of lower limb muscle from both groups decreased markedly（ P〈0. 01）,especially that of soleus; and Hongyi capsules could reduce the changes（ P〈0. 05）; 3） Hongyi capsules showed significantly protection on 45 d HDBR-reduced muscle volume（ P〈0. 01） of lower limb muscle groups such as bilateral quadriceps,biceps femoris,gastrocnemius and soleus,especially that of soleus（ P〈0. 01）. Conclusion 45 d- 6°HDBR induced progressively muscle atrophy,and the traditional Chinese medicine rhodiola rosea could partially rescue simulated weightlessness-induced lower limb muscle atrophy.

关 键 词：模拟失重 头低位卧床 红益胶囊 肌萎缩 

分 类 号：R856.2[医药卫生—航空、航天与航海医学]