抗N-甲基-D-天门冬氨酸受体脑炎研究进展  

Research progress of anti -N -methyl -D -aspartate receptor encephalitis

作　　者：余小华[1] 束晓梅[1] 

机构地区：[1]遵义医学院附属医院儿科,563003

出　　处：《中华实用儿科临床杂志》2016年第16期1278-1280,共3页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金（31260286）

摘　　要：抗N-甲基-D-天门冬氨酸受体（NMDAR）脑炎是一种以显著的行为异常及精神症状为临床表现的亚急性自身免疫性脑炎，由抗体作用于NMDAR的NR1或NR2亚基所致。本病并非少见，及早诊断及早期免疫治疗能改善预后及减少复发。现就抗NMDAR脑炎流行病学、发病机制、临床表现、诊断、治疗及预后进行综述，以提高临床医师对本病的认识。Anti- N- methyl- D- aspartate receptor （NMDAR） antibody encephalitis is an autoimmune encephalitis manifesting subacutely with prominent aberrant movements and psychiatric symptoms, which associated with antibodies against NR1 or NR2 subunits of the NMDAR. The disease is not rare, early diagnosis and immune treatment can improve prognosis and reduce the recurrence. The epidemiology, mechanisms, clinical presentation, treatment and prognosis of the disease were reviewed in order to enhance the cognition of anti - NMDAR encephalitis.

关 键 词：抗N-甲基-D-天门冬氨酸受体脑炎 异常行为 精神症状 免疫治疗 肿瘤移除 

分 类 号：R742.9[医药卫生—神经病学与精神病学]