慢性硬膜下血肿外膜中转化生长因子-β1的表达及临床意义  

Expression of transforming growth factor-beta 1 in outer membrane of chronic subdural hematoma and its clinical significance

作　　者：马京库 左毅 李宝明 陈尚军 王辉 惠军 谢国强 张彬 吴东飞 董克辛[2] 于清宇[3] 

机构地区：[1]陕西省核工业215医院神经外二科,陕西咸阳712000 [2]大连市友谊医院神经外科,辽宁大连116000 [3]绥化市第一医院神经外科,黑龙江绥化152000

出　　处：《中华神经外科疾病研究杂志》2016年第4期342-345,共4页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的检测慢性硬膜下血肿（CSDH）外膜中转化生长因子-β1（TGF-β1）的表达情况。方法应用免疫组化检测32名慢性硬膜下血肿患者血肿外膜中TGF-β1的表达情况。在5个高倍视野下每张切片中的成纤维细胞、血管内皮细胞、炎细胞数大于500个为富于细胞组，共16例，在100—500之间为较丰富细胞组，共12例，小于100个为缺乏细胞组，共4例。结果TGF-β1在富于细胞组表达呈强阳性。在较丰富细胞组表达呈阳性。结论TGF-β1促进血肿外膜新生血管生成，促进血肿外膜纤维化。Objective The expression of transforming growth factor-beta 1 （TGF-beta 1 ） in the outer membrane of chronic subdural hematoma （CSDH） was detected. Methods The expression of TGF-beta 1 was detected in the outer membrane of 32 patients with chronic subdural hematoma by using immunohistochemical technique. At high magnification ×5, the number of fibroblasts, endothelial ceils, and inflammatory cells in each section more than 500 was divided into cell abundance group （ 16 cases）, the number between 100 and 500 was the cell rich group （12 cases）, and the number less than 100 was cell deficiency group （4 cases）. Results TGF-beta 1 was strong positively expressed in cell abundance group, and was positively expressed in the cell rich group. Conclusion TGF-beta 1 promotes the angiogenesis in outer membrane of hematoma and the fibrosis of outer membrane of hematoma.

关 键 词：慢性硬膜下血肿 转化生长因子-Β1 血肿外膜 新生血管生成 纤维化 

分 类 号：R739.4[医药卫生—肿瘤]