女性复发性抑郁症共病心境恶劣的临床特征  

Clinical features of female patients with recurrent major depression comorbidity with dysthymia

作　　者：汪周兵 陶晟 武文庆 魏燕 张广华 张震 

机构地区：[1]镇江市精神卫生中心,212000

出　　处：《临床精神医学杂志》2016年第4期220-223,共4页Journal of Clinical Psychiatry

基　　金：中国复旦大学附属华山医院;英国牛津大学惠尔康人类遗传研究中心和美国维吉尼亚州大学国际合作项目(A283);镇江市科技支撑计划-社会发展(SH2011063)镇江市科技计划(社发科技支撑)项目(SH2014095);镇江市卫生科技重点专项项目(SHW2015011;SHW2015012)

摘　　要：目的:探讨女性复发性抑郁症患者共病心境恶劣的临床特征。方法:采用复合性国际诊断用检查访谈(CIDI)将301例女性复发性抑郁症患者分为共病心境恶劣组(共病组,26例)及非共病心境恶劣组(非共病组,275例);对两组的人口学资料、抑郁症临床特征、父母亲情关系量表(PBI)、艾森克神经质量表、生活应激事件量表评分进行比较。结果:两组人口学资料比较差异无统计学意义;与非共病组的临床资料相比,共病组抑郁症总病程更长[(14.1±9.5)年vs.(10.4±8.3)年;P=0.032],起病年龄更小[(30.9±8.3)岁vs.(36.1±9.4)岁;P=0.003],发病次数更多[(5.8±5.3)vs.(4.1±4.9);P=0.047],阳性家族史及有自杀行为比率更高(34.6%vs.18.5%,P=0.049;38.5%vs.20.4%,P=0.033);艾森克神经质评分明显增高[(13.3±6.0)vs.(10.6±5.7);P=0.025];二元Logistic回归分析显示,PBI母亲保护评分、共病焦虑障碍及生活压力事件是共病心境恶劣的因素(P<0.05或P<0.01)。结论:共病心境恶劣的女性复发性抑郁症患者其抑郁症病情更为严重;母亲过度保护、共病焦虑障碍及生活压力事件是其相关因素。Objective： To explore the clinical features of female patients with recurrent major depression （MD） eomorbid with dysthymia. Method： Using composite international diagnostic use checks interview （CIDI） ,301 female recurrent MD patients were divided into comorbidity dysthymia group （26 cases） and non- comorbidity dysthymia group （275 cases）. The demographic data, the clinical features of depression, scores of parents relationship scale （PBI）, Eysenck neuroticism scale, stress life events scale were compared between the two groups. Results：There were no significant difference in demographic data between the two groups. Compared to non-comorbidity dysthymia group,the MD duration in comorbidity dysthymia group was longer [ （14.1 ± 9.5） years vs. （ 10.4 ± 8.3 ） years; P = 0. 032 ], the age of onset was earlier [ （ 30.9 ± 8.3 ） vs. （ 36.1 ± 9.4） ;P =0.003] ,the times of MD recurrent was more [ （5.8±5.3） vs. （4.1±4.9） ;P =0.047] ,the rate of MD family historyand incidence of suicide attempt were higher （34.6% vs. 18.5 %, 38.5 % vs. 20.4% ;all P 〈 0. 05 ） ; the score of Eysenck neuroticism was higher [ （ 13.3 ± 6.0 ） vs. （ 10.6 ±5.7 ） ; P = 0.025 ]. The score of PBI mathernal protectiveness, comorbid with anxiety disorder, and suffered from serious life events were correlated with comorbidity dysthymia（ P 〈 0.05 or P 〈 0.01 ）. Conclusion： Female patients who comorbidity with recurrent MD and dysthymia have worse depression symptoms. PBI maternal protectiveness, comorbid with anxiety and stressful life events are the related factors of the comorbidity.

关 键 词：复发性抑郁症 心境恶劣 共病 女性 临床特征 

分 类 号：R749.4[医药卫生—神经病学与精神病学]