三氧水灌注引流治疗癌性腹腔积液的临床观察  

Clinical Observation of Ozonated Water Perfusion Drainage in Treating Malignant Ascites

作　　者：付海艳 马克 杨继群 王洁 张洁 万焱 徐斌 

机构地区：[1]昆明市第三人民医院关怀科,云南昆明650000

出　　处：《肿瘤药学》2016年第4期271-274,共4页Anti-Tumor Pharmacy

摘　　要：目的观察腔内灌注三氧水对癌性腹腔积液的临床效果以及对患者生活质量的影响。方法选择我科2014年10月-2015年12月收治的96例癌性腹腔积液患者为研究对象,随机分为两组,实验组51例引流后给予三氧水腹腔灌注,每次灌注量为100 m L,每日2次,7天为1疗程,对照组45例给予放腹水联合间断输注血浆白蛋白利尿治疗,治疗后评价和比较两组的疗效、生活质量的改善情况及不良反应的发生情况。结果实验组完全缓解9例,部分缓解21例,稳定7例,无效11例,总有效率62.5%;对照组完全缓解2例,部分缓解15例,稳定8例,无效18例,总有效率39.5%,实验组总有效率显著高于对照组(P=0.029)。实验组QOL改善稳定率79.2%,对照组QOL改善稳定率62.7%,两组差异有统计学意义(P=0.017)。两组不良反应的发生情况比较,差异无统计学意义(P>0.05)。结论三氧水灌注引流治疗癌性腹腔积液可以更有效地提高晚期肿瘤患者的生活质量。Objective To observe the effcacy and quality of life of intaperitoneal Ozonated Water in treating patients with malignant peritcneal effusions. Methods A total of 96 cases of malignant ascites patients treated in our department form October 2014 to December 2015 were taken as the research objects. They were randomly divided into two groups. 51 cases in the research group were given peritoneal perfusion with Ozonated water after proper drainage. The amount of Ozonated water was 100 ml per time, two times a day and 7 days for a cycle of treatment. 45 cases in the control group were given human blood albumin infusion and discontinuous diuretic therapy after paracentesis. Evaluate and compare the effects of the two groups after treatment, as well as the improvement of the quality of life and the occurrence of adverse reactions. Results There were 9 cases of CR, 21 cases of PR, 7 cases of SD, and 11 cases of PD in the research grouP, with an overall responses rate of 62.5%. In the control group, there were 2 cases of CR, 15 cases of PR, 8 cases of SD and 18 cases of PD, and overall responses rate was 39.5%. The overall responses rate in the research group was obviously higher than in the control group （P= 0.029）. The QOL improvement stability rate was 79.2% in the research group, but 62.7% in the control group, with statistical difference between the two groups （P=0.017）. Yet there were no significant differences in adverse reactions between the two groups （P 〉 0.05）. Conclusion Ozonated Water perfusion drainage in treating malignant ascites can improve the quality of life of patients with advanced malignant tumor.

关 键 词：三氧水 灌注引流 癌性腹腔积液 临床疗效 生活质量 

分 类 号：R730.5[医药卫生—肿瘤]