多发性硬化患者中枢灰质损伤与临床症状的相关性研究进展  

Correlation between grey matter damage and clinical symptom of multiple sclerosis:research advances

作　　者：苌浩晓 陈光亮[2] 尹琳琳[1] 

机构地区：[1]首都医科大学宣武医院药物研究室,北京市老年病医疗研究中心,北京市神经药物工程技术研究中心,北京100053 [2]安徽中医药大学中西医结合临床学院,合肥230038

出　　处：《国际药学研究杂志》2016年第4期675-676,687,共3页Journal of International Pharmaceutical Research

基　　金：北京市科技新星计划资助项目(Z12111000250000);北京市卫生系统高层次卫生技术人才-学科骨干资助项目(2014-3-052)

摘　　要：一般来说,多发性硬化(MS)的病理改变以中枢白质病变为主,然而,由于MS患者出现的认知功能障碍等临床表现无法完全用白质病变来解释,因此MS患者中枢灰质损伤日益受到重视。高场强磁共振成像技术(MRI)的发展使得能在患者出现临床症状的同时清晰地观察其灰质病变,但患者临床症状与中枢灰质(特别是皮质)病变之间的相关性仍需深入研究。因此,本文将对MS疾病进程中患者中枢灰质损伤与临床症状(主要包括认知障碍和癫痫等)的关系做一综述。Generally,the pathological changes of multiple sclerosis（MS）is mostly on lesion of the central white matter（WM）. However,the clinical symptoms such as cognitive impairment cannot be fully explained just by the WM damage. Therefore,central gray matter（GM）damage has attracted more attention. The development of magnetic resonance imaging（MRI）makes in vivo detection of GM while showing the clinical symptoms possible. Yet,the correlation between the patient clinical symptoms and GM damage particularly in cortex still need to be elucidated. Hence,we summarize the historical background and give an overview of the correlation between GM damage and MS clinical symptoms in terms of cognitive impairment and epilepsy.

关 键 词：多发性硬化 灰质损伤 认知障碍 临床表现 

分 类 号：R744.51[医药卫生—神经病学与精神病学]