基于非经典矿化结晶理论的牙本质仿生再矿化机制及仿生分子的研究进展  

The mechanism of dentin biomimetic remineralization based on the non- classical crystallization pathway theory and the research progress on non- collagenous proteins analogues

作　　者：林轩东[1] 谢方方[1] 

机构地区：[1]广西医科大学附属口腔医院,广西南宁530021

出　　处：《牙体牙髓牙周病学杂志》2016年第8期507-512,共6页Chinese Journal of Conservative Dentistry

基　　金：广西自然科学基金(2011GXNSFA01829);广西高校科学技术研究一般项目(2013YB056);广西医疗卫生适宜技术研究开发项目(S201305-01)

摘　　要：牙本质再矿化对于预防和治疗牙本质龋、牙本质过敏症都具有重要的临床意义,因此利用生物材料实现牙本质再矿化并形成有序的自然矿化结构一直都是口腔医学界的研究热点。随着对自然矿化机制研究的不断深入,以主张胶原纤维内部矿化作为主要矿化方式的非经典矿化理论逐步取代了经典矿化结晶学说,并已成为当代仿生再矿化新的理论指导。本文就再矿化理念的发展、矿化机制和仿生分子的研究进展作一综述。Dentin remineralization is of much clinical significance in the prevention and treatment of dentin caries and dentin hypersensitivity. Therefore,the exploration of biological materials for dentin remineralization to form an orderly natural mineralized structure has risen much interest in dentistry. In recent years,the classical pathway of ion- mediated crystallization is gradually replaced by non- classical crystallization pathway which advocates intrafibrillarmine ralization. This review summarizes the development of dentine remineralization theory,the mechanism of mineralization,and research progress on non- collagenous proteins（ NCPs） analogues.

关 键 词：非胶原蛋白 仿生再矿化 微创治疗 

分 类 号：R781.2[医药卫生—口腔医学]