骨肉瘤AP方案化疗后预防性使用粒细胞集落刺激因子的时机探讨  

Discussion on the Timing of Prophylactic Use of G-CSF After AP Chemotherapy for Patients with Osteosarcoma

作　　者：张菁[1] 宫晨[1] 张鹏[1] 熊华[1] 熊慧华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤科,湖北武汉430030

出　　处：《中国血液流变学杂志》2015年第4期409-411,475,共4页Chinese Journal of Hemorheology

基　　金：国家自然科学基金资助项目（81372434）

摘　　要：目的：探讨骨肉瘤AP方案化疗后预防性使用粒细胞集落刺激因子（G-CSF）的时机。方法将90例骨肉瘤患者随机分为3组：化疗后24 h、化疗后48 h及化疗后72 h使用G-CSF组，记录各组患者中性粒细胞计数，了解发生重度中性粒细胞减少的情况，并观察有无发热、口腔黏膜炎及腹泻。结果3组患者发生重度中性粒细胞减少的情况差异具有统计学意义（P﹤0.005）。进行两两分组比较，可见24 h组与48 h组（P﹤0.005）、24 h组与72 h组（P﹤0.05）差异均有统计学意义，而48 h组与72 h组（P﹥0.05）差异无统计学意义。结论在化疗后24 h使用G-CSF，发生重度中性粒细胞减少的风险明显高于化疗后48 h及72 h。Objective To investigate the best timing of prophylactic use of G-CSF after AP chemotherapy for patients with osteosarcoma.Methods 90 patients with osteosarcoma were randomly divided into three groups： using G-CSF 24 h after chemotherapy, 48 h after chemotherapy and 72 h after chemotherapy. Record the absolute neutrophil counts, severe neutropenia, and observe the occurrence of fever, mucositis and diarrhea.Results There was a signiifcant difference （P﹤0.005） between the three groups. Further analysis showed that there were signiifcant difference between 24 h and 48 h group （P﹤0.005）, 24 h and 72 h group （P﹤0.05）, but not between 48 h and 72 h group （P﹥0.05）.Conclusion The risk of severe neutropenia was signiifcantly higher in using G-CSF 24 h after chemotherapy than 48 h and 72 h after chemotherapy.

关 键 词：骨肉瘤 AP方案化疗 预防性使用 使用时机 

分 类 号：R738.1[医药卫生—肿瘤]