急性脑梗死患者NIHSS评分与血管性血友病因子抗原、D-二聚体的关系  

Correlation Between NIHSS Score and von Willebrand Factor Antigen, D-Dimer in Patients with Acute Cerebral Infarction

作　　者：冯红选[1] 程庆璋[1] 石冬敏[2] 

机构地区：[1]南京医科大学附属苏州医院神经内科,江苏苏州215002 [2]南京医科大学附属苏州医院检验科,江苏苏州215002

出　　处：《中国血液流变学杂志》2015年第4期430-432,533,共4页Chinese Journal of Hemorheology

摘　　要：目的：探讨急性脑梗死患者NIHSS评分与血管性血友病因子抗原（vWF：Ag）、D-二聚体（D-D）的关系。方法2011年4月—2012年4月采用免疫比浊法测定急性脑梗死患者94例及同期健康体检者120名（对照组）血管性血友病因子抗原、D-二聚体，并进行比较分析。结果两组血管性血友病因子抗原（212.60±75.77 vs 111.19±40.43，P﹤0.001）、D-二聚体（231.94±112.65 vs 133.05±94.38，P﹤0.001）水平差异有统计学意义。血管性血友病因子抗原、D-二聚体与NIHSS评分呈直线正相关（r=0.625、0.510，P﹤0.01）。结论急性脑梗死患者NIHSS评分与血管性血友病因子抗原水平、D-二聚体的关系密切，病情越重，血管性血友病病因子、D-二聚体越高，可作为急性脑梗死患者病情严重程度的评估因子。ObjectiveTo study the correlation between NIHSS score and von Willebrand factor antigen （vWF：Ag）, D-dimer （DD） in patients with acute cerebral infarction.MethodsData was collected from 94 case of acute cerebral infarction patients who was diagnosed by Department of Neurology of Suzhou Hospital Afifliated to Nanjing Medical University from April 2011 to April 2012. At the same time, 120 healthy subjects were served as control group. vWF：Ag, DD were measured by immune nephelometry. The difference about vWF：Ag, DD was discussed between both groups.Results The difference between both groups was as follows： vWF：Ag （212.60±75.77 vs 111.19±40.43,P﹤0.001）, DD （231.94±112.65 vs 133.05±94.38,P﹤0.001）. vWF：Ag, DD showed a signiifcant positive correlation with NIHSS （r=0.625, 0.510,P﹤0.01）. vWF：Ag correlated positively and signiifcantly with DD （r=0.688,P﹤0.01）.Conclusion NIHSS score is closely associated with vWF：Ag, DD in patients with acute cerebral infarction.

关 键 词：血管性血友病因子抗原 D-二聚体 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]