细胞致死性扩张毒素和外膜蛋白的结构功能和致病机制  

Structural function and pathogenic mechanism of cytolethal distending toxin and outer membrane proteins

作　　者：孙菲[1] 张建刚[2] 肖水清[2] 

机构地区：[1]滨州医学院口腔学院正畸教研室,滨州256603 [2]济南市口腔医院正畸科,济南250001

出　　处：《国际口腔医学杂志》2016年第5期565-568,共4页International Journal of Stomatology

基　　金：济南市科技局企业创新计划(201121038)~~

摘　　要：伴放线放线杆菌是青少年牙周病的主要致病菌,与侵袭性牙周炎密切相关。伴放线放线杆菌细胞致死性扩张毒素(CDT)和外膜蛋白(OMP)等毒力因子使其更易定植到宿主体内,破坏宿主的免疫调节,从而进一步引起牙周组织破坏和加速牙周病的进展。本文主要就CDT和OMP毒力因子目前的结构功能及致病机制作一综述,以期对其深入研究有所帮助。Actinobacillus actinomycetemcomitans（A.actinomycetemcomitans） is the main pathogenic bacteria of juvenile periodontal diseases and is associated with aggressive periodontitis. A.actinomycetemcomitans cells secrete synthetic cytolethal distending toxin（CDT） and outer membrane protein（OMP）, which can be easily planted into the host to destroy immunity function. Thus, the presence of these molecules leads to the progression of periodontal tissue destruction and periodontal diseases. This paper mainly describes the structural function and pathogenic mechanism of the two virulence factors, namely, CDT and OMP, for further research.

关 键 词：伴放线放线杆菌 细胞致死膨胀毒素 外膜蛋白 

分 类 号：R781.4[医药卫生—口腔医学]