血肿抽吸术对脑出血后早期基质金属蛋白酶-9的影响  

Effect of hematoma aspiration on matrix metalloproteinase-9 after intracerebral hemorrhage

作　　者：蒋令修[1] 薛孟周 梁宇[1] 陈文武[1] 孙永梅[1] 卜一多 李香[1] 方建[1] 黄荣[1] 李云霞[1] 

机构地区：[1]河南大学第一附属医院神经内科,开封475000 [2]第四军医大学一旅五营十九连,西安710000

出　　处：《中国实用神经疾病杂志》2016年第14期8-10,共3页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金面上项目(81471174)

摘　　要：目的探讨血肿抽吸术治疗脑出血对患者血清基质金属蛋白酶-9水平的影响。方法选择脑出血患者60例的临床资料进行回顾性分析,其中30例采用血肿抽吸术治疗为研究组,30例采用保守治疗为对照组,比较2组治疗前后血清MMP-9水平,分析MMP-9与NDS的相关性,以及患者的预后情况。结果 2组血清MMP-9水平均在治疗后2d达到高峰,但研究组的高峰值显著低于对照组,差异有统计学意义(P<0.01);随后MMP-9水平逐渐下降,但研究组治疗后7d及14dMMP-9水平均显著低于对照组,差异有统计学意义(P<0.01)。2组治疗后NDS评分均显著低于入院时,差异有统计学意义(P<0.01);研究组治疗第14天研究组NDS评分显著低于对照组,差异有统计学意义(P<0.01)。研究组和对照组血清MMP-9水平与NDS评分具有显著的正相关性(P<0.01)。研究组总有效率90.0%,对照组为63.3%,研究组显著高于对照组,差异有统计学意义(P<0.05)。结论脑出血患者采用血肿抽吸术治疗,治疗后能够显著降低MMP-9的高峰值,有利于改善患者的预后。Objective To explore the effect of hematoma aspiration on matrix metalloproteinase-9 （MMP-9） after intracerebral hemorrhage. Methods Clinical data of 60 patients with intracerebral hemorrhage were collected and analyzed re- spectively. 30 cases were treated with hematoma aspiration as study group,another 30 cases of control group were treated with medications. MMP-9 levels of two groups before and after treatment were collected and compared, relationships between MMP-9 and NDS （neurological functional defect scale score） as well as clinical efficacy were observed. Results MMP-9 levels in the serum of both groups reached the peaks after 2 days with treatments, but the MMP-9 peak level of study group was significantly lower than that of control group （P〈0.01） ;However, MMP-9 levels of both groups decreased, but MMP-9 levels of study group were significantly lower than that of control group at the day 7 and day 14 following intracerebral hemorrhage （P 〈0.01）. NDS scores in both groups after treatment were significantly lower than those before treatment （P%0.01）. After treatment, NDS scores of study group were significantly lower than that of control group （P〈0.01）. MMP-9 levels in serum showed positive correlation with NDS （P〈0.01）. Total efficacy rate of study group was 90.0%, and control group was 63.3%, which showed significant difference （P〈0.05）. Conclusion Hematoma aspiration for intracerebral hemorrhage can reduce MMP-9 peak level, which may help to improve the prognosis of patients with intracerebral hemorrhage.

关 键 词：血肿抽吸术 脑出血 基质金属蛋白酶-9 

分 类 号：R743.34[医药卫生—神经病学与精神病学]