动态增强MRI半定量及时间-信号强度曲线对原发性肝细胞肝癌的诊断价值  

Diagnostic Value of Semi-Quantitative Dynamic-enhanced MRI and Time-Signal Intensity Curve for Primary Hepatocellular Carcinoma

作　　者：高鑫[1] 张磊[1,2] 

机构地区：[1]安徽医科大学解放军306临床学院,北京100101 [2]解放军306医院医学影像科,北京100101

出　　处：《解放军医药杂志》2016年第8期56-60,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨动态增强MRI半定量分析及时间-信号强度曲线在原发性肝细胞肝癌(primary hepatocellular carcinoma,HCC)诊断中的应用价值。方法对2011—2015年经病理组织学证实或临床影像综合分析确诊的22例HCC患者共22个病灶的影像学资料进行回顾性分析,均行9期动态增强扫描。分别测量HCC病灶和正常肝组织感兴趣区的相对信号强度增加值、峰值信号增强百分比、增强斜率及廓清斜率。根据信号强度增加值绘制时间-相对信号增强曲线;对HCC病灶和正常肝组织半定量参数进行分析。结果本组中HCC的时间-相对信号增强曲线类型分为廓清型95%(21/22)及上升平台型5%(1/22),HCC病灶峰值信号增强百分比、增强斜率高于正常肝组织(P<0.01),HCC病灶廓清斜率与正常肝组织比较差异无统计学意义(P>0.05)。结论时间-信号强度曲线形态可直观反映病灶内对比剂的流入及廓清情况,通过半定量分析间接反映肿瘤新生血管情况,对HCC有一定诊断意义。Objective To investigate application of semi-quantitative dynamic-enhanced magnetic resonance imaging（ MRI） and time-signal intensity curve in diagnosis of primary hepatocellular carcinoma（ HCC）. Methods Iconography data of 22 HCC patients（ 22 lesions） from 2011 to 2015 confirmed by histopathology or clinical imaging analysis was retrospectively analyzed. All patients underwent a total of 9 phases of dynamic-enhanced MRI scanning. Relative increase value of signal intensity,peak signal enhancement percentage,enhancement slope and clearance slope of the interested region in HCC lesions and normal hepatic tissues were detected respectively. Time-relative signal intensity curve was drawn according to value of signal intensity,and semi-quantitative parameters of HCC lesions and hepatic tissues were analyzed. Results Types of HCC time-relative signal intensity curve in this study were 95%（ 21 /22） of clearance type and 5%（ 1 /22） of rise platform type. Values of peak signal enhancement percentage and enhancement slope of HCC lesions were significantly higher than those of hepatic tissues（ P〈 0. 01）,but there was no significant difference in clearance slope between HCC lesions and hepatic tissues（ P〉 0. 05）. Conclusion The shape of time-signal intensity curve can directly reflect inflow and clearance conditions of contrast medium,and semi-quantitative parameter analysis can indirectly reflect tumorous neovessels characteristics,and therefore it is helpful for HCC diagnosis.

关 键 词：肝肿瘤 动态增强 磁共振成像 半定量 时间-信号强度曲线 

分 类 号：R735.7[医药卫生—肿瘤]