颅内静脉窦血栓形成患者纤维蛋白原D-二聚体与预后的相关性  

Correlation of fibrinogen,D-dimer and prognosis in patients with cerebral venous sinus thrombosis

作　　者：肖喜春[1] 谷月丽[1] 代全德[2] 路文革[2] 

机构地区：[1]河南商丘市第一人民医院血液内科,商丘476100 [2]河南商丘市第一人民医院神经内科,商丘476100

出　　处：《中国实用神经疾病杂志》2016年第15期19-20,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨静脉窦血栓形成(CVST)患者纤维蛋白原、D-二聚体与短期预后的关系。方法选取CVST患者56例为CVST组,检测血浆纤维蛋白原、D-二聚体,并与50例健康者(对照组)作对照。按改良Rankin量表(mRS)评分,将CVST患者再分为预后良好组和预后不良组,并对比2组纤维蛋白原、D-二聚体水平。结果静脉窦血栓形成患者组D-D、Fbg分别为(316.37±14.59)ng/mL、(4.96±1.27)g/L,均显著高于对照组;预后良好组D-D、Fbg分别为(289.34±22.37)ng/mL、(4.58±1.16)g/L,均显著低于CVST预后不良组。结论血浆纤维蛋白原、D-二聚体对于CVST的诊断和短期预后判断有重要临床价值。Objective To investigate the relationship between fibrinogen,D-dimer and short term prognosis in patients with venous sinus thrombosis （CVST）. Methods Fifty-six cases of CVST patients admitted to the hospital were selected as CVST group,plasma fibrinogen and D-dimer were detected and 50 cases of healthy people were selected as control group. According to the modified Rankin Scale （MRS） score, CVST were subdivided into good prognosis group and poor prognosis group,and fibrinogen and D-dimer of two groups were compared. Results D-D,FBG in venous sinus thrombosis patients was respective （316.37 ± 14.59 ） ng/mL, （4.96± 1.27） g/L, which was significantly higher than those of control group ; D-D, FBG in good prognosis group was respective （289.34 ±22.37） ng/mL, （4.58 ± 1.16） g/L, which was significantly lower than CVST group with a poor prognosis. Conclusion Plasma fibrinogen and D-dimer have important clinical value for diagnosis and prognosis of CVST patients.

关 键 词：静脉窦血栓形成 纤维蛋白原 D-二聚体 短期预后 

分 类 号：R743.32[医药卫生—神经病学与精神病学]