消化系统肿瘤中纤维蛋白原及D-二聚体的表达及临床价值  

Expression of D-Dimer and Fibrinogen and its Clinical Significance in Patients with Digestive System Tumor

作　　者：魏炎[1] 李锴男[1] 毕经旺[1] 

机构地区：[1]中国人民解放军济南军区总医院肿瘤科,山东济南250031

出　　处：《生物技术通讯》2016年第4期542-544,共3页Letters in Biotechnology

摘　　要：目的:探讨血浆纤维蛋白原和D-二聚体在消化系统肿瘤中的表达水平和临床价值。方法:测定215例消化系统常见恶性肿瘤患者及50名健康人员血浆中纤维蛋白原和D-二聚体的含量并进行比较。结果:恶性肿瘤患者血浆纤维蛋白原和D-二聚体增高,与健康对照组比较差异有统计学意义(P<0.05);Ⅲ+Ⅳ期肿瘤患者纤维蛋白原和D-二聚体水平明显高于Ⅰ+Ⅱ期患者(P<0.05);不同肿瘤类型患者的血浆纤维蛋白原和D-二聚体水平差异无显著性。结论:纤维蛋白原、D-二聚体检测对消化系统肿瘤的实验室诊断和疾病分期可能具有重要作用。Objective： To study the expression and clinical significance of plasma fibrinogen and D-dimer in pa-tients with digestive system tumor. Methods： Two hundred and fifteen patients with digestive system tumor and fif-ty healthy controls were included in the study. The levels of fibrinogen and D-dimer in plasma had been deter-mined. Results： The plasma level of fibrinogen and D-dimer was significantly higher in patients with digestive sys-tem tumor than in controls（P〈0.05）. The fibrinogen and D-dimer level in the tumor patients of Ⅲ or Ⅳstageswas significant higher than in those of Ⅰ or Ⅱ stages（P〈0.05）. And there were no significant differences befounded in different groups of patients with digestive system tumor（P〈0.05）. Conclusion： Detection of plasma fi-brinogen and D-dimer may contribute to the laboratory diagnosis and stage evaluation in digestive system tumor.

关 键 词：纤维蛋白原 D-二聚体 消化系统肿瘤 

分 类 号：R735[医药卫生—肿瘤]