抗癌新药NSC319726对卵巢癌基因表达影响的研究  

The effects of anti-cancer drug NSC319726 on the gene expression of ovarian cancer

作　　者：邓燕红[1] 乐秀[2] 高文超[3] 

机构地区：[1]广州医科大学附属第三医院,广州510150 [2]中山大学药学院 [3]中山大学附属第三医院

出　　处：《实用肿瘤学杂志》2016年第4期332-338,共7页Practical Oncology Journal

摘　　要：目的研究抗癌新药NSC319726对卵巢癌基因表达的影响。方法下载GEO数据库,研究NSC319726对卵巢癌细胞系TOV112D影响的数据,进行生物信息学分析。结果 NSC319726上调卵巢癌细胞246个基因、下调198个基因;上调基因包括MMP3与CXCR4等,下调基因包括PBX1等。GO分析中,我们发现6个GO条目与物质代谢有关。Pathway分析发现,NSC319726可以影响生物钟及MMP信号通路相关基因。结论抗癌新药NSC319726可影响卵巢癌细胞系中多个功能基因的表达,因此它可能是前体B细胞急性淋巴细胞白血病潜在的治疗药物。但需要注意的是,NSC319726也可能对肿瘤转移、人体睡眠产生不利影响,故临床运用前有待更多研究。Objective To study the effects of anti -cancer drug NSC319726 on the gene expression of ovarian cancer.Methods The data that NSC319726 acted on the ovarian cancer cell lines TOV112D was down-loaded from the GEO database and then the bioinformatical analysis was conducted .Results NSC319726 in-creased 246 genes including MMP3,CXCR4 et al and decreased 198 genes such as PBX1 in ovarian cancer cell lines.GO analysis indicated that six GO items were related to metabolism .Pathway analysis revealed that NSC319726 could affect the circadian clock and MMP signaling pathway .Conclusion NSC319726 could affect the expression of multiple functional genes in ovarian cancer cell lines and might be a potential drug targeting to the precursor-B cell acute lymphoblastic leukemia .Meanwhile , it should be noted that NSC 319726 may have effects on the tumor metastasis and human sleep .Therefore,further research needs to be conducted before the clinical use .

关 键 词：NSC319726 卵巢癌 生物信息学分析 GO分析 MMP信号通路 

分 类 号：R737.31[医药卫生—肿瘤]