VEGF、TrKB及Flt-4表达水平与老年鼻咽癌患者肿瘤侵袭、转移的相关性分析  

Correlation between VEGF,Tr KB,Flt-4 expression and tumor invasion,metastasis in elderly patients with nasopharyngeal carcinoma

作　　者：魏刚[1] 

机构地区：[1]天津医科大学总医院检验科,天津300052

出　　处：《现代医学》2016年第7期969-971,共3页Modern Medical Journal

摘　　要：目的:探讨鼻咽癌组织中血管内皮生长因子(VEGF)、酪氨酸激酶受体B(Tr KB)、血管内皮生长因子受体-4(Flt-4)与肿瘤侵袭、转移的关系。方法:选择60例鼻咽癌患者为研究组,62例正常鼻咽组织为对照组。采用免疫组化法检测两组组织中VEGF、Tr KB与Flt-4的表达量,分析其与肿瘤侵袭、转移的相关性。结果:60例鼻咽癌患者中VEGF、Tr KB及Flt-4的阳性表达率分别为85.00%、86.67%及88.33%,与对照组比较,差异均有统计学意义(P<0.05)。VEGF、Tr KB及Flt-4的表达与年龄无关(P>0.05),与临床分期、淋巴结转移有关(P<0.05)。结论:组织中VEGF、Tr KB及Flt-4的高表达促进鼻咽癌肿瘤淋巴血管的生成,导致肿瘤侵袭和转移。Objective： To discuss the relationship between vascular endothelial growth factor（ VEGF）,tyrosine kinase B（ Tr KB）,fms-like tyrosine kinase-4（ Flt-4）,and invasion and metastasis of nasopharyngeal carcinoma（ NPC）.Methods： Immunohistochemical staining（ SP） was used to detecting the expression of VEGF,Tr KB and Flt-4 in 60 specimens of NPC and 62 of normal tissues. The relationship between tumor＇s clinicopathologic characteristics and lymph node metastasis was analyzed. Results： In 60 cases of NPC,positive expression rates of VEGF,Tr KB and Flt-4 were85. 00%,86. 67% and 88. 33% respectively,which were significantly different compared with the control group（ P〈0. 05）. The positive expression of VEGF,Tr KB and Flt-4 in NPC was significantly correlated with clinic stage and lymph node metastases groups（ P〈0. 05）. No significant differences of VEGF,Tr KB and Flt-4 expression were found in the different age groups（ P〈0. 05）. Conclusions： The high expression of VEGF,Tr KB and Flt-4 might promote tumor invasion and metastasis by inducing lymphangiogenesis in NPC tissue.

关 键 词：鼻咽癌 血管内皮生长因子 酪氨酸激酶受体B 血管内皮生长因子受体-4 淋巴结转移 

分 类 号：R739.62[医药卫生—肿瘤]