低频重复经颅磁刺激对卒中后抑郁患者认知和日常生活能力的影响  

Effects of low frequency repetitive transcranial magnetic stimulation on cognitive and daily life ability of patients with post stroke depression

作　　者：邢效如[1] 赵新春[1] 王魁恩[1] 孙志[1] 

机构地区：[1]中国人民解放军第254医院神经内科,天津300142

出　　处：《国际精神病学杂志》2016年第4期648-650,654,共4页Journal Of International Psychiatry

摘　　要：目的探讨卒中后抑郁(PSD)患者采取低频重复经颅磁刺激(r-TMS)治疗的疗效。方法选取120例于2014年5月至2015年5月期间我院接收的卒中抑郁患者伴轻度认知障碍患者共120例,按随机数字表格法平均分为对照组与实验组。对照组予以盐酸氟西汀胶囊治疗和心理治疗等常规抗抑郁治疗,实验组则在对照组的基础上加用低频重复经颅磁刺激治疗。观察两组患者治疗前后汉密尔顿抑郁量表(HAMD),简易精神状态检查量表(MMSE),蒙特利尔评估量表(Mo CA),巴塞尔指数(BI)评分的变化。结果两组患者在治疗前上述表格评分,组间无明显差异(P>0.05);治疗后,两组患者上述量表结果与治疗前相比均好转,且差异有统计学意义(P<0.05)。且实验组的HAMD评分,Mo CA评分、MMSE评分、BI指数评分上,实验组均显著优于对照组(P<0.05)。结论在常规抗抑郁治疗的基础上,合并低频r-TMS可更显著改善PSD患者的认知功能、日常生活能力及抑郁症状,临床疗效肯定。Objective To investigate the effect of low frequency repetitive transcranial magnetic stimulation（rTMS）on cognitive and daily life ability of patients with post stroke depression（PSD）. Methods 120 patients with post stroke depression were recruited in our hospital from May 2014 to May 2015 for this research. According to random number table method,all the patients in the study were divided into the control group and the experimental group averagely,60 cases for each. The control group were received the conventional anti depression treatment such as Fluoxetine Hydrochloride Capsules therapy and psychotherapy,while the experimental group were given r-TMS on the basis of what the control group received. Before and after treatments,HAMD,MMSE,Mo CA and BI index of the two groups were evaluated and compared.. Results There was no statistical difference of all the scales mentioned above between the two groups before treatments（P0.05）. After therapy,compared with before it,the scores of HAMD,MMSE,Mo CA and BI index were much better in the both two groups,all the differences had statistical significances（P0.05）.While compared with the control group,the scores of HAMD,MMSE,Mo CA and BI index of the experimental group were much better,all the differences had statistical significances（P0.05）.Conclusion r-TMS treatment on the basis of the conventional anti depression treatment can be more effective to improve the cognitive function,daily life ability and depressive symptoms of patients with PSD,it＇s has definite clinical curative effect.

关 键 词：卒中后抑郁 低频重复经颅磁刺激 日常生活能力 认知功能 

分 类 号：R749.05[医药卫生—神经病学与精神病学]