重组组织型纤溶酶原激活剂(rt-PA)联合脑室外引流对重型脑室出血患者颅内压升高的治疗效果分析  

Curative Effect Analysis of rt-PA Therapy Combined with EVD in Patients with Intraventricular Hemorrhage

作　　者：徐开明[1] 郭强[2] 张耀华[1] 

机构地区：[1]北京大学深圳医院急诊外科,518036 [2]北京大学深圳医院神经外科,518036

出　　处：《岭南急诊医学杂志》2016年第4期333-334,368,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨在行脑室外引流(extraventricular drainage,EVD)的重度脑室出血患者中应用rt-PA治疗对ICP的控制效果。方法:从包括北京大学深圳医院在内的深圳市三家医院内与神经外科合作随机选出122例阻塞性脑室内出血且进行脑室外引流急救的患者,随机分成脑室内重组组织型纤溶酶原激活剂(rt-PA)治疗组(n=97)以及阴性对照组(未予溶栓)(n=25),比较rt-PA治疗对于颅内压升高的影响。结果:rt-PA治疗组患者ICP升高程度低于对照组,且脑室血肿清除天数明显低于对照组。结论:溶栓治疗联合脑室外引流能明显控制IVH患者颅内压的升高,且有助于脑室血肿的清除,具有一定的临床意义,可扩大病例数进行大样本的验证。Objective ： To analyze the curative effect of rt-PA therapy for patients underwent EVD with IVH.Method：122 patients with obstructive IVH required emergency EVD were selected randomly in three hospitals in Shenzhen including Peking University Shenzhen Hospital. All the patients were divided into two groups randomly ：Patients treated with intraventricular recombinant tissue plasminogen activator（rt-PA）（n =97）; Patients treated without thrombolytic therapy（n=25）. Results ： ICP elevation was significantly lower in patients treated with rt-PA,and the days of visible blood clearance were significantly shorter. Conclusion ： Thrombolytic therapy united with EVD could prevent the elevated ICP of patients with IVH, and could reduce the days of visible blood clearance.

关 键 词：颅内压 脑室外引流 溶栓治疗 脑室出血 

分 类 号：R743.34[医药卫生—神经病学与精神病学]