2％普萘洛尔乳膏治疗婴幼儿增殖期草莓状血管瘤的临床效果  

Clinical efficacy of topical propranoiol cream on strawberry hemangiomas in proliferative phase

作　　者：张幸存[1] 杨云川[1] 王元元[1] 高扬[1] 张军波[1] 王海淋 鲁元刚[1] 

机构地区：[1]第三军医大学大坪医院整形美容科,重庆400042

出　　处：《中华医学美学美容杂志》2016年第4期218-220,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的观察2％普萘洛尔乳膏治疗婴幼儿增殖期草莓状血管瘤（SH）的临床效果和安全性。方法选取符合标准的婴幼儿增殖期SH患者60例，其中男18例，女42例，年龄30d至12个月；病变位于头颈部30例，躯干19例，四肢11例。给予2％普萘洛尔乳膏外涂，3次／d。治疗期间每月定期复诊，动态观察和记录血管瘤大小、质地和颜色变化等，并随时处理治疗过程中出现的不良反应。采用4级评分法对近期疗效进行评定。所有患儿治疗结束后随访12个月。结果疗效评价显示，Ⅰ级2例，Ⅱ级17例，Ⅲ级33例，Ⅳ级8例。所有患儿均未发生明显不良反应。结论2％普萘洛尔乳膏治疗婴幼儿增殖期草莓状血管瘤的疗效满意，不良反应小，具有一定的临床推广价值。Objective To observe the efficacy and safety of topical 2% propranolol cream for strawberry hemangiomas in proliferative phase. Methods Sixty infants with strawberry hemangiomas in proliferative phase were included in this study. There were 18 males and 42 females aged 30 days to 12 months. The lesions were located in head and neck （n=30）, trunk （n：19） and extremities （n= 11）. All the infants received the 2% propranolol cream treatment three times per day. The infants were required a regular return visit every month. The changes of tumor size, texture and color were monitored and recorded. The adverse effects after medication were observed and managed accordingly. The short-term results were evaluated using a 4-grade system. Results All the infants were followed up for 12 months. Among 60 infants, the Ⅰ,Ⅱ,Ⅲ and IV grade curative effects were 2, 17, 33 and 8 cases, respectively. All the infants had no drug adverse reaction. Conclusions The effect of topical 2% propranolol cream for strawberry hemangiomas in proliferative phase is reliable, with little side effects. It will be popularized in clinical application.

关 键 词：普萘洛尔乳膏 婴幼儿 草莓状血管瘤 

分 类 号：R732.2[医药卫生—肿瘤]