原发性肝癌患者血清前白蛋白、特异性生长因子、甲胎蛋白含量分析  

Analysis of the contents of serum prealbumin,tumor specific growth factor and α- fetoprotein in patients with primary liver cancer

作　　者：邹长进[1] 

机构地区：[1]枝江市人民医院,湖北枝江443200

出　　处：《中国卫生检验杂志》2016年第15期2214-2215,2218,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的观察原发性肝癌(PLC)患者血清前白蛋白(PAB)、特异性生长因子(TSGF)、甲胎蛋白(AFP)含量变化,探讨三者对PLC的临床运用价值。方法回顾分析PLC患者85例(PLC组,其中临床Ⅰ期25例、临床Ⅱ期32例、临床Ⅲ期28例)、良性肝病组90例(良性肝病组)、同期体检健康人群90例(对照组),平行检测各组及PLC组治疗(手术或介入治疗)后人群血清PAB、TSGF、AFP含量,进行统计学分析。结果治疗前PLC组、良性肝病组、对照组血清PAB含量依次增高,而血清TSGF、AFP含量依次降低,差异均有统计学意义(P<0.01)。PLC患者血清PAB含量与TSGF、AFP含量呈负相关(r值分别为-0.864、-0.649,P<0.01);血清TSGF含量与AFP呈正相关(r=0.954,P<0.01)。PLC组手术后和介入治疗后血清PAB、TSGF、AFP含量与PLC组治疗前比较,差异均有统计学意义(P<0.01)。结论联合检测PLC患者血清PAB、TSGF、AFP含量,对PLC的诊断及预后具有一定的意义。Objective To observe the content changes of serum prealbumin（ prealbumin,PAB）,specific growth factor（ tumor specific growth factor,TSGF,a tire protein（ α- fetoprotein,AFP） in patients with primary liver cancer（ primary liver cancer,PLC） and discuss the value of clinical application in PLC. Methods To enroll 85 patients with PLC（ PLC group,the clinical stage Ⅰ25 cases,clinical stageⅡ 32 cases,clinical stage Ⅲ 28 cases）,90 cases of benign liver disease group（ benign liver disease group）,90 healthy examination volunteer during the same period of physical examination as control（ control group）.The content changes of serum PAB,TSGF,AFP of different groups and PLC treatment group（ surgery or interventional therapy）were conducted parallel test. Results Before the treatment,the content of serum PAB in PLC group,benign liver disease group and control group increased in turn,but the contents of serum TSGF,AFP reduced in turn,the differences were statistically significant（ P〈0. 01）. The content of serum PAB in PLC patients was negatively correlated with the content of serum TSGF,AFP（ r =- 0. 864,- 0. 649,P〈0. 01）; the content of serum TSGF,AFP were positively correlated（ r = 0. 954,P〈0. 01）. The contents of serum PAB,TSGF,AFP in PLC group after surgery or interventional treatment were compared with PLC group after surgery or interventional treatment,and the difference had statistical significance（ P〈 0. 01）. Conclusion Combined detecting serum PAB,TSGF and AFP levels in patients with PLC has a certain significance for the diagnosis and prognosis of PLC.

关 键 词：原发性肝癌 前白蛋白 特异性生长因子 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]