Novel Total Synthesis of Mansouramycin B  

作　　者：Yi Zhang Xiaoxin Shi Tianzhuo Meng Qiqi Fan Xia Lu 

机构地区：[1]Department of Pharmaceutical Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

出　　处：《Chinese Journal of Chemistry》2016年第7期683-688,共6页中国化学（英文版）

基　　金：the National Natural Science Foundation of China （No. 20972048） for the financial support of this work.

摘　　要：A novel total synthesis of Mansouramycin B （1） was performed via 10 steps in 28% overall yield starting from the readily available and cheap salicylaldehyde. Two key steps of this total synthesis are noteworthy. The first one is base-promoted one-pot aerobic aromatization of N-tosyltetrahydroisoquinoline 6, the second one is oxidation of 5-hydroxy-3-methyl-isoquinoline 8 with iodobenzene diacetate [PhI（OAc）2].A novel total synthesis of Mansouramycin B （1） was performed via 10 steps in 28% overall yield starting from the readily available and cheap salicylaldehyde. Two key steps of this total synthesis are noteworthy. The first one is base-promoted one-pot aerobic aromatization of N-tosyltetrahydroisoquinoline 6, the second one is oxidation of 5-hydroxy-3-methyl-isoquinoline 8 with iodobenzene diacetate [PhI（OAc）2].

关 键 词：Mansouramycin B total synthesis ISOQUINOLINE QUINONE ALKALOID SALICYLALDEHYDE 

分 类 号：O[理学]