血清睾酮水平与围绝经期抑郁症的相关性研究  

Association between testosterone and perimenopausal depression in women

作　　者：惠凌云[1] 王亚文[1] 张琳[1] 侯宁蕊[1] 于学文[1] 

机构地区：[1]西安交通大学第一附属医院,西安710061

出　　处：《中国妇幼卫生杂志》2016年第4期1-4,共4页Chinese Journal of Women and Children Health

摘　　要：目的流行病学及临床研究显示,妇女心理问题的发生率高于男性,尤其是在性激素迅速变化时期。本研究的目的是探讨围绝经期女性睾酮水平与抑郁症发生的相关性。方法根据汉密尔顿抑郁量表(HDRS)评分及ICD-10"抑郁发作"的诊断标准筛选70例研究对象,包括围绝经期抑郁组和青年抑郁组,另选取同期查体健康的妇女60例为对照组(包括围绝经期和青年组)。采集晨起空腹外周血,采用电化学发光法检测血清睾酮水平。结果抑郁症妇女血清睾酮水平低于正常妇女(0.38 nmol/L vs 0.82 nmol/L,P<0.05),尤其是围绝经期抑郁症组妇女睾酮水平最低(0.299 nmol/L),低于其他3组(P<0.05);睾酮水平与HDRS评分存在负相关关系[Exp(B)=0.141,P=0.008],睾酮水平也与围绝经期HDRS评分存在负相关关系[Exp(B)=0.100,P=0.003]。结论血清睾酮水平降低与抑郁症发生有关,尤其是围绝经期抑郁。适当的血清睾酮水平可能有助于减少围绝经期抑郁症的发生。Objective Epidemiological and clinical data have unequivocally supported the notion that women experience more psychiatric problems during their lives,particularly in the transitional phase of menopause. The aim of the study is to explore the relationship between the testosterone level and perimenopausal depression in women. Method Women with depression,after meeting criteria in the international statistical classification of diseases and related health problems 10 th revision for mental and behavioural disorders and the 17-item Hamilton Depression Rating Scale（ HDRS）,were included in the study. Psychosocial data and blood samples were obtained from the subjects in the study,including 38 perimenopausal and 32 young women with depression,26 healthy control perimenopausal and 34 young women. The serum testosterone was detected by electrochemiluminescence assay. Result Compared with controls group,women with depression had Serum lower testosterone level（ 0. 38 nmol / L vs. 0. 82 nmol / L,P〈 0. 05）,and depressed perimenopausal women exhibited the lowest serum testosterone levels（ 0. 299 nmol / L）. Logistic regression analyses showed that testosterone levels were inversely correlated with HDRS scores in the women [Exp（ B） = 0. 141,P = 0. 008] and it was still inversely correlation between testosterone levels with HDRS scores in the perimenopausal women [Exp（ B） = 0. 100,P = 0. 003].Conclusion The results provide evidence of association between depressive symptom severity and decreasing testosterone levels in perimenopausal women. The optimal testosterone level in serum may contribute to reduce occurrence of perimenopausal depression.

关 键 词：睾酮 围绝经期 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]