基于一种酰腙和咪唑配体的铜(Ⅱ)、镍(Ⅱ)配合物的水热合成、晶体结构及体外抗癌活性  

Syntheses,Crystal Structures and in Vitro Antitumor Activities of Copper(Ⅱ) and Nickel(Ⅱ) Complexes Based on Acylhydrazone and Imidazole Ligands

作　　者：高平章[1] 陈雅心 郑敏敏[1] 王景梅[1] 解庆范[1] 陈延民[1] 

机构地区：[1]泉州师范学院化工与材料学院,泉州362000

出　　处：《无机化学学报》2016年第9期1572-1578,共7页Chinese Journal of Inorganic Chemistry

基　　金：泉州师范学院学科建设资金;福建省大学生创新创业训练计划项目(No.201510399025;201510399030)资助

摘　　要：采用水热法合成了5-硝基水杨醛缩噻吩-2-甲酰腙的铜和镍配合物[Cu(Him)L]2(1)和[Ni(Him)L](2)(H2L=5-硝基水杨醛缩噻吩-2-甲酰腙,Him=咪唑)并经元素分析、红外光谱和紫外光谱表征。X射线单晶衍射分析表明,1的晶体属单斜晶系,空间群P21/c,晶胞参数:a=1.135 68(12)nm,b=0.770 45(8)nm,c=2.140 4(2)nm,β=97.405(3)°。2的晶体属三斜晶系,空间群P1,晶胞参数:a=0.726 91(4)nm,b=0.976 34(6)nm,c=1.265 74(8)nm,α=79.533(2)°,β=82.862(2)°,γ=68.985(2)°。1是中心对称的双核配合物,Cu(Ⅱ)处于四方锥配位环境;2是单核配合物,Ni(Ⅱ)处于平面四边形的配位环境。化合物1通过N-H…O氢键形成一维超分子链,而化合物2通过N-H…O和C-H…O氢键形成二维超分子网络。初步研究了配体和配合物的体外抗癌活性。结果表明,配合物1和2对人肝癌细胞HEPG2和人结肠癌细胞SW620均有较强的增殖抑制作用。Two new complexes [Cu（Him）L]2（1） and [Ni（Him）L]（2）,where H2 L is 2-thiophenecarboxylic acid（2-hydroxly-5-nitro-benzylidene）-hydrazide and Him is imidazole,were synthesized by hydrothermal reaction and characterized by elemental analysis,FT-IR and electronic spectra.The structure of complexes has been accomplished by single crystal X-ray diffraction which results confirmed that the crystal of 1 belongs to the monoclinic system,space group P21/c with cell parameters：a=1.135 68（12） nm,b=0.770 45（8） nm,c=2.140 4（2）nm,β=97.405（3）° and the crystal of 2 belongs to the triclinic system,space group P1 with cell parameters：a=0.726 91（4） nm,b=0.976 34（6） nm,c=1.265 74（8） nm,α =79.533（2）°,β=82.862（2）°,γ =68.985（2）°.The X-ray analyses revealed that 1 displays a centrosymmetric binuclear structure with the Cu atoms in square pyramidal coordination.The binuclear units are further linked by hydrogen bonds to generate an infinite 1D chain.The mononuclear units in 2 are linked through weak N-H … O and C-H … O hydrogen bonds to form an infinite 2D network.The in vitro antitumor activities of ligand and complexes were tested by MTT method,which results show that 1 and 2 have strong in vitro antitumor activity against HEPG2 and SW620 cancer cells lines.

关 键 词：酰腙 配合物 晶体结构 抗癌活性 

分 类 号：O614.121[理学—无机化学] O614.813[理学—化学]