高同型半胱氨酸血症与脑梗死、帕金森病的相关性研究  

Investigation of the Correlation of High Hcy Hyperlipidemia and Cerebral Infarction,and PD

作　　者：邱观养[1] 邓耀芳[1] 黄丹丹[1] 吴泳[1] 崔明志[1] 

机构地区：[1]广东省高州市人民医院神经内科,广东高州525200

出　　处：《黑龙江医学》2016年第8期677-678,共2页Heilongjiang Medical Journal

摘　　要：目的对脑梗死、帕金森和高同型半胱氨酸(Hcy)血症相互之间的关系展开探析,以便为疾病的防治提供参考依据。方法选取2014-07—2015-07间高州市人民医院所收治的脑梗死与帕金森病(Parkinson sdisease,PD)患者各40例,分别将其作为甲组、乙组;将同时期来院做身体检查的健康人40例作为丙组,以高效液相色谱法,对三组患者的血浆Hcy水平进行检测与比较。之后,对甲、乙两组患者补充B族维生素(维生素B6、B12)与叶酸,并将其干预前后的血浆Hcy水平及NIHSS评分改善情况进行对比。结果三组患者的血浆Hcy水平相比较,差异有统计学意义(P<0.05);甲乙两组患者干预后的血浆Hcy水平、NIHSS/VPDRS评分均低于本组干预前,差异有统计学意义(P<0.05);甲乙两组患者干预后的血浆Hcy水平相比,差异无统计学意义(P>0.05)。结论高Hcy血症和脑梗死、PD之间有着十分密切的关系,其是脑梗死、PD的危险因素。Objective To explore the relationship of cerebral infarction,Parkinson and high Hcy hyperlipidemia to provide reference for the prevention and treatment of diseases. Methods 40 patients with Parkinson＇s disease and cerebral infarction from July,2014 to July,2015 were selected,and they were divided into Group A and Group B; physical examination of 40 healthy people was regarded as Group C. Through high performance liquid chromatography,plasma Hcy levels of patients of three groups were detected and compared. Thereafter,the Group A and B got B vitamins（ vtb6,vtb12） and folic acid,and its plasma Hcy levels before and after the intervention and NIHSS score improvement were compared. Results Plasma Hcy levels of patients of three groups were compared,with statistically significant difference（ P〈0. 05）; plasma Hcy levels and NIHSS / VPDRS rates of Group A and B after the intervention were lower than before intervention,and the difference was statistically significant（ P〈0. 05）. Through comparing plasma Hcy levels of Group A and B,there was no significant difference（ P〉0. 05）. Conclusion There is close relationship between high Hcy hyperlipidemia and cerebral infarction,and PD. It is the risk factor of cerebral infarction and PD.

关 键 词：脑梗死 帕金森 高同型半胱氨酸血症 

分 类 号：R743.33[医药卫生—神经病学与精神病学]