肺癌18F-FDG PET／CTSUVmax值与临床因素及肿瘤标志物相关性研究  

Correlation of SUV_(max) measured in ^(18)F-FDG PET/CT with clinical factors of lung cancer and tumor markers

作　　者：程凯[1] 葛鲁娜[2] 付正[1] 

机构地区：[1]山东大学附属山东省肿瘤医院PET-CT室,山东省医学科学院,山东济南250117 [2]山东省医药生物技术研究中心,山东济南250062

出　　处：《中华肿瘤防治杂志》2016年第13期884-887,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：山东省医药卫生科技发展计划(2014WS0058)

摘　　要：目的原发肿块最大标准化摄取值(maximal standard uptake value,SUVmax)为PET/CT常用的半定量指标,被广泛用于肿瘤的诊断与治疗评估。本研究探讨肺癌18 F-FDG PET/CT的SUVmax值与临床各因素及肿瘤标志物的相关性,为肺癌临床诊断和治疗提供依据。方法回顾性分析2014-01-09-2015-03-17山东省肿瘤医院收治82例肺癌患者(腺癌32例,鳞癌19例,小细胞癌12例,混合型肺癌5例,类癌4例,大细胞癌4例,未分类癌6例)治疗前PET/CT影像资料及相关的临床资料,探讨18F-FDG PET/CT的SUVmax值与病理分型、性别、年龄、淋巴结转移及肿瘤标志物的相关性。结果腺癌SUVmax均值为9.65±6.02,显著低于小细胞肺癌的14.20±5.33,差异有统计学意义,P<0.05;细胞角蛋白19片段(cytokeratin fragmet antigen21-1,CYFRA21-1)升高组、神经元特异性烯醇化酶(neuron-specific enolase,NSE)升高组SUVmax均值分别为13.16±5.99和14.09±6.05,均显著高于相应正常组的9.17±5.09和9.73±5.37,差异有统计学意义,P<0.05;不同性别、有无淋巴结转移、癌胚抗原(carcino-embryonic antigen,CEA)是否升高之间,SUVmax均值差异均无统计学意义,P>0.05。相关性分析显示,SUVmax与年龄、病灶大小均无相关性;与NSE呈低度相关,r=0.361,P=0.003。结论肺癌18 F-FDG PET/CT的原发肿块SUVmax值与病理类型、CYFRA21-1和NSE有关。肺腺癌患者SUVmax均值低于小细胞肺癌,CYFRA21-1和NSE升高组SUVmax均值升高,SUVmax与NSE水平呈低度相关。OBJECTIVE SUV which has been widely used in diagnosis and treatment the semi-quantitative parameter of PET/CT. The objective of this study was to investigat measured in 18 F-FDG PET/CT with clinical factors of lung cancer and tumor markers, and p evaluation is always used as e the correlation of SUV rovide diag nosis and treatment of lung cancer. METHODS The clinical data of 82 cases of lung cancer treated from January 9, 2014 to March 17, 2015 were analyzed retrospectively（32 cases of adenocarcinoma, 19 cases of squamous carcinoma, 12 cases of small cell carcinoma,5 cases of mixed type of lung cancer, 4 cases of carcinoid tumor, 4 cases of large cell carcinoma, 6 cases of unclassified carcinoma）. The correlation of SUV measured in 18F-FDG PET/CT with pathological types, gender, age, lymph node metastasis and tumor markers was explored. RESULTS The average SUVmax of adenocarcinoma was 9.65±6.02 which was significantly lower than that in small cell carcinoma of 14.20±5.33 and the difference was statically significant （P〈0.05）. The value of SUVmax in CYFRA21-1 el.evated group and NSE elevated group were 13.16±5.99 and 14.09±6.05. They were significantly higher than those in normal groups of 9. 17±5. 09 and 9. 73±5. 37 （P〈0.05）. The average SUVr.ax of different gender groups, lymph node metastasis and CEA levels had no difference （P〉0.05）. Correlation analysis showed that SUVmax and age, tumor size had no correlation, a low correlation with NSE （r=0. 361, P=0. 003）. CONCLUSIONS The SUVmax value is related to the pathological types, the levels of CYFRA21-1 and NSE. The average SUV of adenocarcinoma is lower than that in small cell carcinoma. The value of SUVmax in CYFRA21-1 elevated group and NSE elevated group rose. SUVmax have a low correlation with NSE.

关 键 词：肺肿瘤18F-FDG PET/CT SUVmax值 临床因素 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]