FOXC2和E-cad在结肠癌组织中的表达及临床意义  

Expression and clinical significance of FOXC2 and E-cad in colon cancer tissues

作　　者：王静苗 贾喜花[1] 王晓博[1] 艾晓晴[1] 宋泰宁 

机构地区：[1]保定市第一中心医院肿瘤内科,河北保定071000

出　　处：《临床肿瘤学杂志》2016年第8期718-721,共4页Chinese Clinical Oncology

摘　　要：目的探讨结肠癌组织中叉头框蛋白C2(FOXC2)、E-钙粘附蛋白(E-cad)的表达及临床意义。方法收集2014年1月至2016年3月70例结肠癌组织和30例癌旁组织,采用免疫组织化学SP法检测上述组织中FOXC2、E-cad的表达情况,分析两者的相关性及与临床病理特征的关系。结果 FOXC2在结肠癌组织中的阳性表达率为74.3%(52/70),高于癌旁组织的20.0%(6/30),差异有统计学意义(P<0.001);E-cad在结肠癌组织中的阳性表达率为21.4%(15/70),低于癌旁组织的80.0%(24/30),差异有统计学意义(P<0.001)。FOXC2和E-cad在结肠癌组织中的表达与TNM分期、浸润深度、淋巴结转移有关(P<0.05),与年龄、性别、肿瘤大小、分化程度无关(P>0.05)。在结肠癌组织中两者表达呈负相关(r=-0.728,P<0.05)。结论 FOXC2在结肠癌组织中高表达,而E-cad呈低表达,且两者表达呈负相关,提示FOXC2、E-cad可能共同参与了结肠癌的发生、发展过程。Objective To investigate the expression and clinical significance of forkhead C2（FOXC2） and E-cadherin （E- cad） in colon cancer tissues. Methods From Jan 2014 to Mar 2016, 70 cases of colon cancer and 30 adjacent nornlal tissues were collected. Imnmnohistochemical SP method was used to determine the expression of FOXC2 and E-cad in those tissues. The correlation of the two proteins in colon cancer tissues, and the relationship of the two proteins with pathological features were analyzed. Results The expression of FOXC2 （74. 3%, 52/70） in colon cancer tissues was significantly higher than that in adjacent normal tissues （20. 0%, 6/30） with sIatistic significance（P〈0. 001 ）. The expression of E-cad（21.4%, 15/70） in colon cancer tissnes was lower than that in adjacent normal tissues（ 80. 0%, 24/30） with statistic significance（P〈0. 001 ）. The expression of FOXC2 and E-cad was related with TNM staging of tumor, depth of invasion and lymph node metastasis （P〈0. 05） , and no association was observed in age, gender, tumor size and histological grading（ P〉0. 05）. The two proteins were negatively correlated in colon cancer tissues（ r =-0. 728, P〈0. 05）. Conclusion FOXC2 shows high expression in colon cancer tissues, while E-cad is low expressed. Meanwhile, a negative correlation is observed between the two proteins, suggesting that FOXC2 and E-cad inay be involved in the occurrence and development of colon cancer.

关 键 词：叉头框蛋白C2(FOXC2) E-钙粘附蛋白(E-cad) 结肠癌 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]