新疆地区5577例原发性肝癌的流行病学特点分析  

Epidemiological analysis of 5 577 cases of primary liver cancer in Xinjiang

作　　者：路鹏霏 毛睿[1] 马静[1] 汪慧才 张宋安[1] 吴戈[1] 包永星[1] 

机构地区：[1]新疆医科大学第一附属医院肿瘤中心,乌鲁木齐830054

出　　处：《中华健康管理学杂志》2016年第4期270-274,共5页Chinese Journal of Health Management

摘　　要：目的分析新疆地区原发性肝癌（PHC）的临床流行病学特点，为制定合适的防治措施提供参考。方法收集整理2002年1月至2014年12月新疆医科大学第一附属医院诊疗的5577例PHC患者的临床资料，对其性别、族别、发病年龄、户口分布、肝炎病毒阳性率进行回顾性分析。结果5577例PHC患者中，男女之比为3．45：1；汉族、维吾尔族、哈萨克族、回族及其他民族（锡伯族、满族、蒙古族）所占的比例分别为79．67％、9．86％、4．55％、3-31％、2．61％，且维吾尔族与汉族的构成比差异有统计学意义（P〈0．05）。4232例患者进行了乙型肝炎表面抗原（HBsAg）检测，3833例患者进行了丙型肝炎抗体（HCV—Ab）检测。HBsAg呈阳性者2560例（60．49％），HCV．Ab呈阳性者490例（12．78％）；维吾尔族的乙型肝炎病毒检测阳性率为35．52％，哈萨克族的乙型肝炎病毒检测阳性率为40．00％，均低于汉族（65．68％，P〈0．05）。PHC患者中城市人口与农村人口分别为3589例（64．35％）和1988例（35．65％）。结论PHC患者易患人群为肝炎病毒阳性患者，新疆地区维吾尔族与哈萨克族PHC患者中的乙型肝炎病毒阳性率明显低于汉族，在临床上应采取相应的防治措施。Objective To analyze the clinical epidemiology of primary hepatocellular carcinoma （PHC） in the Xinjiang region. Methods Clinical data of the patients with PHC were collected at First Affiliated Hospital of Xinjiang Medical University from 5 577 cases from January 2002 to December 2014, their gender, race, age, household distribution, hepatitis virus-positive rate were analyzed retrospectively. Results Among the 5 577 eases, the men/women gender ratio was 3.45 ： 1; the proportion of Han, Uighur, Kazakh, and other ethnic groups （Hui, Mongolian, Manchu, Xibo） was 79.67%, 9.86%, 4.55%, 3.31% and 2.61%, respectively. The Constituent ratio difference between Uighur and Han was significant （P〈0.05）; 4 232 patients had hepatitis B surface antigen （HBsAg） detection, and 3 833 patients had HCV antibody （HCV-Ab） detection. HBsAg was positive in 2 560 cases （60.49%）, HCV-Ab was positive in 490 cases （12.78%）. Hepatitis B virus detection positive rate in Uygur was 35.52%, in Kazak was 40.00%, which was lower than the Han＇s （65.68%, P〈0.05）. Urban and rural population had 3589 cases （64.35%） and 1988 cases （35.65%）. Conclusion An increased risk for PHC was found in hepatitis virus-positive patients, the Xinjiang Uygur and Kazak people had significantly lower prevalence of HBV infection than the Han＇s. Appropriate measures should be taken for clinical diagnosis, treatment and prevention of PHC.

关 键 词：肝肿瘤 流行病学 原发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]