半夏泻心汤治疗腹泻型肠易激综合征临床观察  

Clinical Observation of Banxia Xiexin Tang for Diarrhea-predominant of Irritable Bowel Syndrome

作　　者：刘添文[1] 陈新林[2] 缪旺冬 钟亮环[2] 

机构地区：[1]广东省中医院脾胃病科,广东广州510120 [2]广州中医药大学,广东广州510006

出　　处：《新中医》2016年第8期76-79,共4页New Chinese Medicine

基　　金：广东省中医药局建设中医药强省科研课题(20142071)

摘　　要：目的:观察半夏泻心汤治疗寒热错杂型腹泻型肠易激综合征(D-IBS)患者的临床疗效。方法:将50例寒热错杂型D-IBS患者随机分为治疗组30例、对照组20例。治疗组予半夏泻心汤加减治疗,对照组予得舒特治疗,观察2组治疗前后各症状和生活质量量表(IBS-QOL)评分的变化,检测2组治疗前后血清5-羟色胺(5-HT)水平。结果:治疗组总有效率为93.33%,对照组总有效率为75.00%。2组临床疗效比较,差异有统计学意义(P<0.05)。治疗后,2组腹痛或腹部不适、大便性状、大便次数积分、总积分与治疗前比较均下降(P<0.05),治疗组各症状积分与总积分均低于对照组(P<0.05)。与治疗前比较,2组焦虑不安、行为障碍、躯体意念、健康忧虑、社会功能、性行为积分及总分均较治疗前有不同程度的升高(P<0.05);治疗组健康忧虑积分与总分均高于对照组(P<0.05)。结论:采用辛开苦降法方剂半夏泻心汤治疗寒热错杂型D-IBS可明显改善患者的症状,提高生活质量,疗效显著,其作用机制可能与抑制5-HT过度表达有关。Objective：To observe the clinical effect of Banxia Xiexin tang for diarrhea-predominant of irritable bowel syndrome（D-IBS） with the syndrome of cold and heat mixed complex lesions type.Methods：Divided 50 cases of D-IBS patients with cold and heat mixed complex lesions type into 30 cases of the treatment group and 20 cases of the control group randomly.The treatment group was given addition and subtraction treatment of Banxia Xiexin tang,and the control group was given treatment of Dicetel.Observed changes of every symptom and every dimensionality of quality of life（QOL） in two groups before and after treatment,and detected level of serum 5-hydroxytryptamine（5-HT） in two groups before and after treatment.Results：The total effective rate was 93.33% in the treatment group,and was 75.00% in the control group,the difference being significant（P〈0.05）.After treatment,scores of bellyache orabdominal discomfort,stool property and stool frequency were all decreased（P〈0.05）.Scores of every symptom and total scores in the treatment group were all lower than those in the control group（P〈0.05）.Scores of willies,behavior disorder,body mind,healthy worrying,social function,sexual behaviour and total score in two group were increased in various degree（P〈0.05）.Scores of healthy worrying and total scores in the treatment group were all higher than those in the control group（P〈0.05）.Conclusion：Banxia Xiexin tang by Chinese Medicine methods of acrid to diffuse and bitter to descend for D-IBS with the syndrome of cold and heat mixed complex lesions type can improve symptom and enhance life quality obviously.Its clinical effect is obvious,and its mechanism may relate to inhibiting over expression of 5-HT.

关 键 词：腹泻型肠易激综合征(D-IBS) 寒热错杂证 辛开苦降法 半夏泻心汤 5-羟色胺(5-HT) 

分 类 号：R574.4[医药卫生—消化系统]