IL-18基因启动子区-137G/C,-607G/T、2个位点基因多态性与女性乳腺癌易感性Meta分析  

Association Analysis of IL-18 Gene Promoter Region-137G/C,-607G/T Polymorphisms and Susceptibility to Sporadic Breast Cancer:Meta-Analysis

作　　者：乔雪峰[1] 黄志平[2] 张宁[3] 崔巍[4] 王虹[1] 袁慧茹[1] 吴秀茹[1] 贾静[1] 王晓岩[1] 黄燕[1] 许慧[1] 岳志刚[1] 

机构地区：[1]北京煤炭总医院检验科,北京100028 [2]北京煤炭总医院心脏中心,北京100028 [3]北京煤炭总医院口腔科,北京100028 [4]中国医学科学院北京协和医学院北京协和医院检验科,北京100730

出　　处：《现代检验医学杂志》2016年第4期65-69,73,共6页Journal of Modern Laboratory Medicine

基　　金：煤炭总医院医学科研发展基金(K201602)

摘　　要：目的 用Meta分析的方法综合评价IL-18基因启动子区-137G/C,-607G/T 2个位点基因多态性与女性散发性乳腺癌易感性间的关联性。方法 检索万方数据库Wanfang Data,中国学术期刊数据库CNKI,美国国立医学图书馆PUBMED及荷兰医学文摘EMBASE数据库,搜索有关IL-18基因启动子区多态性与乳腺癌易感性的所有中文或英文期刊文献,并检索纳入文献的 参考文献以防漏检,各数据库检索时限均为自建库始至2015年1月1日止。采用RevMan5.1软件进行不同文献间比值比OR值的合并分析,SAS9.4软件进行Kruskal-Wallis检验,对研究间各研究组组内数据进行纵向分析。结果 初检获得相关文献共计91篇,英文74篇,中文17篇。经筛选最终仅有3篇研究符合要求,共涉及6个研究组893人,包括乳腺癌组476例,健康对照组417例,各研究组人群均符合Hardy-Weinberg遗传平衡。Meta分析结果显示：①-607位点的基因型CC会降低乳腺癌的发病风险,合并后的OR值及95%CI分别为0.75和（0.56,1.00）,总体效应量检验Z=1.97（P=0.05）; Kruskal-Wallis检验显示-607位点和-137位点的乳腺癌组组间比较的检验结果和健康对照组组间比较的检验结果卡方值及P值分别为χ^2=11.809 2,P=0.002 7; χ^2=2.589 3,P=0.274 0和χ^2=7.2936,P=0.006 9; χ^2=0.005 8,P=0.939 5。结论 ①-607位点仅基因型CC与乳腺癌易感性相关联,是乳腺癌发生的保护因素,但等位基因与乳腺癌无关。②研究间结果的异质性主要来源于乳腺癌组。Objective The goal of the present study was to comprehensively evalue the relationship between IL-18 gene pro- moter region -607G/T,-137G/C sites polymorphism and the susceptibility of sporadic breast cancer. Methods Wanfang Database,China national knowledge infrastructure,Pubmed, Embase were retrieved to get all case-control studies from their in- ception to January 1,2015. In addition, references＇ list of the included articles and their related citations were also reviewed for additional articles. Results According the established inclusion criterias,3 studies with a total of cases and controls were identified. The pooled odds ratios and 95% CI for -607 genotype CC were 0.75 and （0.56,1.00）, Z= 1.97 （P = 0.05）. Kruskal-Wallis test show genotype frequency of -607,-137 loci between breast cancer group and healthy group among were significantly different. Chisquare and P were χ^2= 11. 8092, P = 0. 002 7 ; and χ^2= 7. 293 6, P = 0. 0069. Conclusion ① Only CC genotype in -607 loci was associated with susceptibility of breast cancer,and it is a protective factor for breast cancer, but there was no association between the allele and breast cancer. ②The heterogeneity of the results among the 3 studies was mainly derived from the breast cancer group.

关 键 词：乳腺癌 易感性 多态性Meta分析 白细胞介素-18 

分 类 号：R737.9[医药卫生—肿瘤] R730.43[医药卫生—临床医学]