含二茂铁基肟醚类化合物的合成及抗真菌活性  

Synthesis and Antifungal Activity of Oxime-ether Compounds Containing Ferrocenyl

作　　者：赵军龙[1] 张文[1] 苟小锋[1] 花成文[1] 陈邦[1] 

机构地区：[1]西北大学化学与材料科学学院合成与天然功能分子化学教育部重点实验室,陕西西安710069

出　　处：《化学试剂》2016年第9期834-838,874,共6页Chemical Reagents

基　　金：陕西省科学技术研究发展计划项目(2014K08-29);西安市科技局项目(CXY1511(7))

摘　　要：以二茂铁为起始原料,合成了3-二茂铁基-5-芳基吡唑啉,再依次与氯乙酰氯和醛肟反应,生成16个二茂铁基肟醚类化合物。通过^1HNMR、FT-IR及ESI-HRMS对目标化合物进行结构表征。将合成的肟醚类化合物分别对3种植物真菌病（马铃薯干腐病、烟草赤星病、西瓜枯萎病）进行了初步的抗植物真菌活性实验。测试结果显示,部分化合物具有良好的抗植物真菌活性。A series of ferrocenyl oxime-ether derivatives were designed and synthesized from ferrocenyl pyrazoline compounds, chloroacetyl chloride and aldoximes. The structures of the target compounds were confirmed by ^1HNMR, FT-IR and ESI-HRMS. Finally, the primary antimyeotic activity of the title compounds against three plant fungals（ Pythium solani, Gibberlla nicotianeola, Fusarium oxysporium f s. p. niveum. ） had been screened. The results indicate that some of the compounds have a good plant anti-fungal activity.

关 键 词：二茂铁 吡唑啉 肟醚 合成 抑菌活性 

分 类 号：O627.8[理学—有机化学] O625.6[理学—化学]