微波辅助合成盐酸氯卡色林  

Microwave-assisted Synthesis of Lorcaserin Hydrochloride

作　　者：曾碧涛[1] 朱涛[1] 王天霞[1] 

机构地区：[1]宜宾职业技术学院五粮液技术学院,四川宜宾644003

出　　处：《化学试剂》2016年第9期917-920,共4页Chemical Reagents

基　　金：宜宾职业技术学院科技基金资助项目(ybzysc14-45)

摘　　要：在微波辐射条件下,以对氯苯乙酸甲酯为原料,与异丙醇缩合后,经还原、氯化、分子内傅克烷基化成环、酒石酸拆分,最后经游离后与氯化氢气体反应成盐制得盐酸氯卡色林,总收率19.8%。与传统加热法相比,时间缩短90%以上,微波技术合成盐酸氯卡色林的方法具有操作方便、安全、快速、收率高、用时少等特点,具有一定的应用价值。Microwave irradiation was used to synthesize lorcaserin hydrochloride from the 4-chlorophenylacetic ester with the raw material to react with 1-amino-2-propanol. After substitution, Friedel-Crafts alkylation and isomer resolution by tartaric acid, disso- ciation,reaction with hydrogen chloride gas loreaserin hydrochloride was prepared with the total yield of 19.8%. Compared with the conventional method,this method is simple, safe,rapid, efficient and save more than 90% of reaction time. Thus,it could be a promising way for utilization.

关 键 词：盐酸氯卡色林 合成 微波辅助 

分 类 号：R914.5[医药卫生—药物化学]