DDT和B(a)P共暴露下乳腺癌发生的信号转导机制  

Signal Transduction Mechanism of Breast Cancer in Combined Exposure DDT and B(a) P

作　　者：李君[1] 

机构地区：[1]湖北文理学院医学院,湖北襄阳441053

出　　处：《湖北文理学院学报》2016年第8期80-84,共5页Journal of Hubei University of Arts and Science

基　　金：襄阳市科技局科技计划研究与开发项目课题(201310519013)

摘　　要：乳腺癌是目前严重危害女性健康的第一位恶性肿瘤.外源性持久性有机污染物DDT、B(a)P单独暴露经CYP1A1代谢活化可增加乳腺癌发生危险,但DDT、B(a)P共暴露交互作用与乳腺癌关系及分子机制尚未阐明.CYP1A1受mi R-892a靶向调控,DDT、B(a)P共暴露下mi R-892a在人体组织如何表达及靶基因CYP1A1通过何种信号通路诱导乳腺癌分子机制亟需研究.文章对DDT和B(a)P共暴露下mi R-892a及靶基因CYP1A1诱导乳腺癌发生的信号转导机制研究进行综述,并提出可采用体外细胞实验和分子流行病学方法相结合,在器官、细胞及分子水平进行乳腺癌发病机制研究.旨在揭示DDT和B(a)P共暴露在乳腺癌发生中的的交互作用,明确DDT、B(a)P共暴露下mi R-892a及CYP1A1表达与乳腺癌的关系及mi R-892a、CYP1A1诱导乳腺癌发生的信号转导机制,为乳腺癌环境病因学及发病机制研究提供一种新思路、新靶点.Breast cancer is the first malignant tumor impairing women＇s health. Alone exposure exogenous persistent organic pollutants such as DDT and B（a）P through CYP1A1 metabolic activation may increase breast cancer risk. At present the relationship and molecular mechanism relating to interaction of DDT and B（a）P combined ex-posure and breast cancer have not been elucidated. CYP1A1 is a target gene regulated by mi R-892 a.It is urgent to study that mi R-892 a expressing in the human organization and molecular mechanism of CYP1A1 inducing breast cancer in which signal pathway. mi R-892 a and target gene CYP1A1 inducing signal transduction mecha-nism of breast cancer in combined exposure DDT and B（a）P are reviewed.

关 键 词：乳腺癌 mi R-892a 细胞色素P450 1A1 二氯二苯三氯乙烷(DDT) 苯并(A)芘 信号转导 

分 类 号：R737.9[医药卫生—肿瘤]