哈尔滨地区HPV感染现状及年龄的分层分布  

The infection status and age distribution of HPV in Harbin,China

作　　者：于海聪 李佩玲[1] 王红丽[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150006

出　　处：《现代肿瘤医学》2016年第19期3104-3107,共4页Journal of Modern Oncology

基　　金：黑龙江省应用技术研究与开发计划项目(编号:GA14C101-06)

摘　　要：目的：分析哈尔滨地区不同年龄段妇女人乳头状瘤病毒（human papillomavirus,HPV）的感染状况及基因型分布情况。方法：采用导流杂交基因芯片技术,对17 565例女性的宫颈脱落细胞进行HPV-DNA基因分型,分析各组HPV的总感染率和各亚型感染率及其年龄分布特点。结果：HPV总感染率为20.10%（3 531/17 565）。年龄分层显示,以16-20岁感染率（40.12%）最高,且差异有统计学意义（P〈0.005）。高危型以HPV16感染为主,低危型以HPV11感染为主,中国人常见亚型以HPV53感染为主。3 531例阳性标本中,单一感染率明显较多重感染率高（72.70%vs 27.30%,P〈0.005）。HPV感染者中检出率较高的亚型为16型（23.53%）,其次为58型（15.49%）、52型（13.34%）、33型（11.47%）、53型（9.40%）、51型（8.69%）。结论：哈尔滨地区HPV感染具有明显的亚型和年龄分布异质性,且感染年龄趋于年轻化。Objective：To investigate the relationship between subtype HPV infection and different age groups in Harbin,China.Methods：The flow-through hybridization and gene chip technology was used to determine the infec-tion and the genotype of HPV in cervical exfoliated cells for 17 565 women.Results：In 17 565 cases,3 531 cases were detected with HPV-positive infection （20.10%,3 531/17 565）.High-risk HPV infection rate appeared a peak at the age of 16-20 by age stratification with statistical difference （P〈0.005）.HPV16 was the most common high-risk type,and low-risk type subtype was HPV11.The most Chinese common subtype was HPV53.Single HPV type infection rate was significantly higher than multiple HPV type infection rate （72.70%vs 27.30%,P〈0.005）. HPV16（23.53%）was the most common genotype in various types of HPV,followed by HPV58（15.49%）,HPV52 （13.34%）,HPV33（11.47%）,HPV53（9.40%）,HPV51（8.69%）.Conclusion：The subtype-specific and age-specific distribution of HPV infection in Harbin possesses an obvious heterogeneity,and infection tends to be younger.

关 键 词：人乳头状瘤病毒 年龄分布 基因型 

分 类 号：R737.33[医药卫生—肿瘤]