细胞自噬在肿瘤化疗耐药中的作用  

Role of autophagy in cancer chemoresistance

作　　者：李旸[1] 刘卓刚[1] 

机构地区：[1]中国医科大学附属盛京医院血液科,辽宁沈阳110000

出　　处：《现代肿瘤医学》2016年第20期3307-3312,共6页Journal of Modern Oncology

摘　　要：自噬是一种进化上保守的溶酶体依赖的自身降解途径,不仅在保持基因组完整性和维持内环境稳定方面发挥重要作用,也与肿瘤的发生发展和肿瘤耐药密切相关。一方面,保护性自噬能够促进耐药细胞生存;另一方面,自噬作为程序性死亡机制能够直接促进耐药肿瘤细胞死亡。本文综述自噬在肿瘤细胞化疗耐药中的研究进展和相关的信号转导通路,为克服肿瘤多药耐药提供新思路。Autophagy is a conserved intracel lular degradation system which is dependent on lysosome pathway. It is not only responsible for the recycling of metabolites and the maintenance of intracellular ohmeostasis, but also be closely related with tumor development and resistant. On one hand, protective autophagy promote the survival of drugresistant cells, on the other hand, autophagy directly induce death of drugresistant cells as a mechanism of pro-grammed cell death. This paper elucidates the development of autophagy in tumor drug resistance and relative signal pathway to provide new information to overcome drugresistance.

关 键 词：自噬 耐药 化疗 

分 类 号：R730.2[医药卫生—肿瘤]