肝硬化患者APRI的检测及临床意义  

Mensuration and clinical value of APRI in hepatocirrhosis patients

作　　者：田景波[1] 王丽丽[1] 曲燕[1] 刘建军[1] 郭善媛[1] 

机构地区：[1]青岛大学医学院第二附属医院感染性疾病科,266042

出　　处：《中国实用医刊》2016年第16期53-54,共2页Chinese Journal of Practical Medicine

摘　　要：目的：检测肝硬化患者天门冬氨酸氨基转移酶（ AST）和血小板（ PLT）比率指数（ APRI）的变化，分析评估肝功能状态，并探讨其临床意义。方法将68例肝硬化患者按照Child-Pugh分级标准进行评分，分为A、B、C级三组，定量检测血清总胆红素、白蛋白、AST和PLT，根据公式计算出APRI数值，并选取20例正常人作为对照组，进行临床分析。结果肝硬化组APRI显著高于对照组（P﹤0.01）；随Child-Pugh分级的升高而递增，表现为C级﹥B级﹥A级，组间比较差异有统计学意义（P﹤0.01）；与总胆红素存在正相关（P﹤0.01）；与白蛋白存在负相关性（ P﹤0.01）。结论肝硬化患者存在APRI的变化，可反映肝硬化患者肝功能状态，有助于判断肝硬化病情的严重程度，可能有助于肝硬化的诊断治疗和预后判断。Objective To evaluate hepatic function and determine and the clinical significance by detecting the change of numerical value of aspartate aminotransferase-to-platelet ratio index（ APRI）in hepatocirrhosis patients. Methods Sixty-eight hepatocirrhosis patients were divided into three groups of A,B and C by Child-Pugh classification. To test the level of serum total bilirubin,albumin,aspartate aminotransferase and platelet,and count the numerical value of the APRI,and compared the control group with twenty people. Results The numerical value of the APRI in the hepatocirrhosis patients were significantly higher than that in control group（ P﹤0. 01 ）;increased in accord with Child-Pugh classifica-tion,and C﹥B﹥A（P﹤0. 01）;it had the positive correlation with serum total bilirubin（P﹤0. 01）and had negative correlation with alumin（ P﹤0. 01 ）. Conclusions The change of numerical value of APRI may existed in hepatocirrhosis,it could evaluate the degree of hepatic function,show the state of illness and guide the clinical diagnosis and treatment and prognosis.

关 键 词：肝硬化 天门冬氨酸氨基转移酶与血小板比率指数 CHILD-PUGH分级 

分 类 号：R575.2[医药卫生—消化系统]