Ⅰ期非小细胞肺癌病灶中nm23的表达及淋巴结微转移研究  

Stage Ⅰ non-small cell lung cancer and lymph node micrometastases expression of nm23

作　　者：周霖 薛兴阳[2] 

机构地区：[1]深圳市光明新区人民医院普外科,广东深圳518106 [2]广州医科大学附属肿瘤医院胸外科,广东广州510095

出　　处：《中国肿瘤外科杂志》2016年第4期254-256,259,共4页Chinese Journal of Surgical Oncology

摘　　要：目的探讨Ⅰ期非小细胞肺癌(non small cell lung cancer,NSCLC)病灶中nm23的表达及淋巴结微转移情况,以便为临床诊治提供参考。方法选取2005年1月至2010年12月期间深圳市光明新区人民医院接诊的经根治性切除治疗的Ⅰ期NSCLC患者30例进行研究,检测原发癌灶石蜡标本中的nm23基因表达水平,并对常规病理检查为阴性的淋巴结以CK为标志物实施微转移检测。两种测定方式均采用免疫组化法,分析测定结果。结果 30例患者nm23阳性表达率为56.67%,阴性表达率为43.33%;常规病理检出阴性淋巴结132枚中有7例(20枚)检出淋巴结微转移,阳性率分别为23.33%、15.15%;nm23阳性组淋巴结微转移率明显低于阴性组(P<0.05)。结论Ⅰ期NSCLC病灶中nm23表达与淋巴结微转移有相关性,联合检测对病理分期、预后评估等意义重大。Objective To investigate stage Ⅰ non-small cell lung cancer（ NSCLC） expression and lymph node micrometastasis lesions nm23 in order to provide reference for clinical diagnosis and treatment. Methods30 cases of stage Ⅰ NSCLC patients were studied after receiving radical resection,where after primary tumor resection as paraffin determination nm23 gene protein level,whereas the conventional pathological examination was negative lymph nodes（ in CK is a marker） the implementation of micrometastases detected two ways were measured by immunohistochemical methods,measurement results were summarized. Results 30 cases of stageⅠ NSCLC Patients with nm23 positive rate was 56. 67%,negative rate was 43. 33%; routine pathological detection of lymph node negative was 132,7 cases（ 20） the detection of lymph node micrometastasis detection rate and positive rate respectively,23. 33%,15. 15%; nm23 positive lymph node micrometastasis was significantly lower than the negative group（ P〈 0. 05）. Conclusions StageⅠ NSCLC lesions of nm23 and lymph node micrometastases correlated,combined detection of pathological staging,prognostic assessment is of great significance,importance should be strengthened.

关 键 词：非小细胞肺癌 NM23表达 淋巴结微转移 肿瘤标记物 

分 类 号：R734.2[医药卫生—肿瘤]