特应性皮炎与皮肤微生态的研究进展  

Atopic dermatitis and skin microecosystem

作　　者：吴瑕[1] 窦侠[2] 于波[1] 

机构地区：[1]广州医科大学附属北京大学深圳医院皮肤科,深圳518036 [2]北京大学深圳医院皮肤科

出　　处：《国际皮肤性病学杂志》2016年第5期424-426,共3页International Journal of Dermatology and Venereology

基　　金：广东省自然科学基金（2014A030313723）

摘　　要：特应性皮炎是一种慢性、复发性、炎症性皮肤病。其发病机制复杂，在遗传基础上，表皮屏障功能异常、环境过敏原暴露、金黄色葡萄球菌定植等诱发的免疫炎症反应均参与其发病。皮肤微生态是皮肤表面微生物构成的复杂生态系统，近年研究提示，微生态异常在特应性皮炎的发病过程中起重要作用，特应性皮炎患者的皮肤除了存在金黄色葡萄球菌定植增多外，还存在表皮葡萄球菌等其他微生物数量和功能的改变。因此，进一步揭示各种微生物群落与特应性皮炎发病的关系，有助于特应性皮炎的防治。Atopic dermatitis （AD） is a kind of chronic recmTent inflammatory skin disease with complex pathogenesis. The immune-inflammatory responses induced by epidermal barrier dysfunction, exposure to environmental allergens and colonization of Staphylococcus aureus in the context of genetics participate in the pathogenesis of AD. Skin microecosystem is a complex ecosystem which consists of microorganisms on the surface of the skin. Recent studies have shown that abnormal skin microecosystem plays an important role in the pathogenesis of AD. Besides increased S. aureus colonization, there are changes in the quantity and function of other microorganisms such as S. epidermidis on the skin of patients with AD. Therefore, further understanding of the relationship between various microfloras and AD may be helpful to the prevention and treatment of AD.

关 键 词：皮炎 特应性 金黄色葡萄球菌 表皮葡萄球菌 环境微生物学 屏障 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]