IL-35在牙周炎及口腔扁平苔藓中的表达及相关性分析  

The expression and clinical significance of IL-35 in periodontitis and oral lichen planus

作　　者：王玉[1] 靳赢[1] 王奕月[1] 胥丹妮 林晓萍[1] 

机构地区：[1]中国医科大学附属盛京医院口腔科,辽宁沈阳110004

出　　处：《上海口腔医学》2016年第4期443-447,共5页Shanghai Journal of Stomatology

基　　金：高等学校博士学科点专项科研基金(20112104110013);辽宁省科学技术计划项目(2012225015);沈阳市科学技术计划项目(F13-221-9-28)

摘　　要：目的 :探讨IL-35在牙周炎及口腔扁平苔藓免疫机制中的作用及相关影响,以及牙周炎与口腔扁平苔藓之间的相互关系。方法:按纳入标准选择单纯口腔扁平苔藓患者20例,单纯牙周炎患者20例,牙周炎伴口腔扁平苔藓患者20例和健康者12例;记录患者的一般信息及牙周探诊深度、临床附着丧失、牙龈指数、龈沟出血指数,并收集静脉血清及龈沟液样本,采用酶联免疫吸附测定血清及龈沟液中IL-35的表达水平。采用SPSS19.0软件包对数据进行统计学分析。结果:单纯口腔扁平苔藓组、单纯牙周炎组、牙周炎伴口腔扁平苔藓组龈沟液及血清中IL-35浓度显著高于健康对照组(P<0.01),牙周炎伴口腔扁平苔藓组龈沟液及血清中IL-35浓度显著高于单纯口腔扁平苔藓组及牙周炎组(P<0.05);各组牙周临床指标与龈沟液及血清中IL-35表达水平呈正相关关系。结论:牙周炎及口腔扁平苔藓中IL-35表达水平显著升高,其升高程度与两者呈正相关。PURPOSE： To investigate the influence of IL-35 in the pathogenesis of periodontitis and oral lichen planus, and the correlation between periodontitis and oral lichen planus patients. METHODS： The gingival crevicular fluid（GCF） and serum were collected from patients with oral lichen planus （n=20）, periodontitis （n=20）, periodontitis and oral lichen planus （n=20） and healthy controls （n=12）. The patients＇ basic information, probing depth, clinical attachment loss, gingival index, sulcus bleeding index were measured and collected. The expression of IL-35 in GCF and serum was detected by ELISA. SPSS19.0 software package was used for statistical analysis. RESULTS： The concentration of IL-35 in patients with periodontitis and oral lichen planus was significantly higher than that of other groups（P〈0.05）. There was significantly positive correlation between IL-35 level and periodontal clinical parameters. CONCLUSIONS： Periodontitis and oral lichen planus may increase the concentration of IL-35 both in serum and GCF. The expression of IL-35 was positively correlated with periodontitis and oral lichen planus.

关 键 词：白细胞介素35 牙周炎 口腔扁平苔藓 血清龈沟液 

分 类 号：R781[医药卫生—口腔医学]