磷亲核试剂对缺电子烯烃不对称共轭加成反应的进展  

Recent Advances in the Asymmetric Conjugate Addition Reactions of Phosphorus Nucleophiles to Electron-Deficient Alkenes

作　　者：李振[1] 段伟良[2] 

机构地区：[1]上海应用技术学院化学与环境工程学院,上海201418 [2]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032

出　　处：《有机化学》2016年第8期1805-1813,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20902099;21172238;21472218)资助项目~~

摘　　要：手性膦化合物在不对称催化、药物、材料等领域有着广泛的用途.手性膦可作为配体与金属配位或作为有机催化剂用来催化合成光学活性化合物.含膦亲核试剂对缺电子烯烃的不对称共轭加成反应可以用来直接构建手性膦化合物.总结了该领域近年来的主要研究进展,介绍了几类重要的过渡金属催化剂以及小分子催化剂促进的缺电子烯烃的不对称氢膦化反应.Chiral phosphines are very useful in the fields of asymmetric catalysis, pharmaceutical chemistry, and materials. These compounds have been used as ligands coordinated to transition metals or organocatalysts in various reactions to furnish optically active products with high efficiency. Asymmetric phosphorus-addition reaction can be utilized for the direct prepara- tion of chiral phosphorus compounds. This review summarizes the recent progress in the field of enantioselective phospho- rus-addition reactions. Several examples of transition metal- and organocatalyst-promoted asymmetric hydrophosphination reactions of electron-deficient alkenes have been introduced.

关 键 词：不对称加成 膦亲核试剂 手性膦化合物 缺电子烯烃 

分 类 号：O621.251[理学—有机化学]