阿加曲班联合氯吡格雷治疗大动脉粥样硬化性脑梗死的临床研究  

Clinical study on argatroban combined with clopidogrel in the treatment of large artery atherosclerotic cerebral infarction

作　　者：孙贵祥[1] 孙培丽[1] 张爱萍[1] 

机构地区：[1]江苏省如皋市人民医院神经内科,江苏如皋226500

出　　处：《中国当代医药》2016年第19期72-74,共3页China Modern Medicine

摘　　要：目的探讨阿加曲班联合氯吡格雷治疗大动脉粥样硬化性脑梗死的临床疗效。方法选取2015年1月~2016年3月本院收治的60例大动脉粥样硬化性脑梗死患者作为研究对象,随机分为观察组和对照组,各30例。观察组采用阿加曲班联合氯吡格雷进行治疗,对照组采用氯吡格雷进行治疗,比较两组的总有效率以及治疗前后的NIHSS评分。结果观察组治疗1、2周后的NIHSS评分显著低于治疗前,差异有统计学意义（P〈0.05）。观察组治疗1、2周后的NIHSS评分显著低于对照组治疗后,差异有统计学意义（P〈0.05）。观察组的总有效率为87.50%,显著高于对照组的70.00%,差异有统计学意义（P〈0.05）。两组的不良反应发生率比较,差异无统计学意义（P〉0.05）。结论阿加曲班联合氯吡格雷治疗大动脉粥样硬化性脑梗死的临床效果较理想,值得推广应用。Objective To explore the clinical effect of argatroban combined with clopidogrel in the treatment of large artery atherosclerotic cerebral infarction.Methods 60 cases of large artery atherosclerotic cerebral infarction in our hospital from January 2015 to March 2016 were selected and randomly divided into the observation group and the control group,30 cases in each group.The observation group was treated with combination of argatroban and clopidogrel,the control group was treated with clopidogrel.The total effective rate and the score of NIHSS before and after treatment in the two groups was compared.Results The score of NIHSS after treatment for 1 and 2 weeks in the observation group was lower than that before treatment,with significant difference（P〈0.05）.The score of NIHSS after treatment for 1 and 2weeks in the observation group was lower than that in the control group,with significant difference（P〈0.05）.The total effective rate of the observation group was 87.50%,which was higher than 70.00% of the control group,with significant difference（P〈0.05）.There was no significant difference in the incidence rate of adverse reaction between the two groups（P〉0.05）.Conclusion Combination of argatroban and clopidogrel in the treatment of large artery atherosclerotic cerebral infarction can achieve perfect clinical effect,which is worthy of popularization and application.

关 键 词：阿加曲班 氯吡格雷 大动脉粥样硬化性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]