术前粒细胞淋巴细胞比值与血清IL-6水平关系及对胃癌预后的预测作用  

Clinical significances and correlation of serum interleukin-6 and preoperative neutrophil lymphocyte ratio in gastric cancer

作　　者：崔瑶[1] 李剑[2] 刘明月[1] 曹养辉[2] 高天慧[1] 

机构地区：[1]河南省人民医院肿瘤科,郑州450003 [2]河南省肿瘤医院胃肠外科,郑州450008

出　　处：《医药论坛杂志》2016年第7期1-3,6,共4页Journal of Medical Forum

基　　金：河南省科技攻关项目(162102310041)

摘　　要：目的研究粒细胞淋巴细胞比值(NLR)与胃癌临床病理特征、血清IL-6水平及预后的的关系。方法 2011年3月—2012年3月接受手术的胃癌患者,检测患者术前血常规,血清IL-6,计算NLR,记录患者的临床病理特征,随访患者。分析NLR与胃癌临床病理特征、LI-6的关系,多因素分析术后胃癌患者的生存的预后因素。结果 119名接受根治术的胃腺癌患者,TNMⅠ、Ⅱ、Ⅲ、Ⅳ期分别为17(14.3%)、54(45.4%)、45(37.8%)、3(2.5%)人,IL-6升高伴随NLR增加,差异有统计学意义(P<0.05),NLR与TNM分期有关(P<0.05),多因素分析示,高NLR、非R0切除、TNM分期增加为DFS、OS的预后不良因素(P<0.05)。结论 NLR可能与血清IL-6水平有关,高NLR提示胃癌患者预后不良,可作为预后的预测因子。Objectlve To investigate the relationships between the neutrophil lymphocyte ratio （NLR）, serum IL- 6 level, clinical pathological characteristics and survival in gastric cancer. Methods From March 2011 to March 2012, patients with gastric cancer who underwent radical resection were studied. The relationships between clinical characteris- tics and NLR were analyzed using Chi - square test. Predictors of survival were analyzed using multivariate analysis. Results Totally 119 patients receiving radical operation were included. Stage I, and II, and III, and IV patients were 17 （ 14.3% ）, and 54 （45.4%）, and 45 （37.8%）, and 3 （2.5%）, respectively. NLR was related with Serum IL - 6 level （P 〈 0.05 ）, and TNM stage （ P 〈 0.05 ）. Multivariate analysis shows, high NLR, non - R0 resection, and ele- vated stage were correlated with poor DFS and poor OS （P 〈 0. 05 ）. Conclusion High NLR was associated with ele- vated IL - 6 level. High NLR was related with poor DFS and poor OS, it can be used as a predictor of prognosis in gas- tric cancer.

关 键 词：粒细胞淋巴细胞比值 IL-6 胃癌 预后 

分 类 号：R735.2[医药卫生—肿瘤]