天马颗粒剂在抑制结直肠癌术后肿瘤复发中的临床效果  

Analysis of clinical effects about Tianma granules inhibition of tumor recurrence in colorectal cancer

作　　者：彭天书[1] 谢彪[1] 聂甜[2] 胡响当[1] 李梅[1] 杨宗亮[1] 李帅军[1] 王晓艳[1] 罗敏[1] 何永恒[1] 

机构地区：[1]湖南中医药大学第二附属医院,长沙410005 [2]湖南中医药大学第一附属医院,长沙410007

出　　处：《中药药理与临床》2016年第3期191-193,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：湖南省研究生科研创新项目;编号:CX2014B356;湖南省教育厅科学研究项目;编号:14C0874

摘　　要：目的:观察研究天马颗粒剂对结直肠癌术后肿瘤复发和转移的临床抑制效果。方法:选取我科室2007年3月至2010年3月收治疗的确诊为结直肠癌并行手术治疗的患者共120例,按随机数字表发分为治疗组和对照组各60例,治疗组患者术后在常规化疗的基础上给予天马颗粒剂辅助治疗,对照组术后给予常规化疗,随访并记录两组患者肿瘤复发及转移情况、治疗前后免疫指标变化及两组患者治疗过程中毒副反应情况,采用统计学方法对数据进行分析。结果:随访5年后治疗组患者复发生率、总生存率、中位生存时分别为(49.2%、52.71%、42.56月)均明显优于对照组(67.3%、36.48%、28.13月)。随访一个疗程后治疗组主要免疫指标Ig A、Ig M、Ig G、C3分别为(0.81±0.23、0.72±0.24、8.13±1.05、1.59±0.21)g/L均明显优于对照组(0.65±0.15、0.60±0.15、6.45±0.89、0.95±0.20)g/L。治疗组腹泻、神经炎、肝功异常、白细胞下降、血小板下降等副反应例数均少于对照组,但仅腹泻有显著性差异。结论:天马颗粒剂能明显提高结直肠癌患者术后生存质量,提高患者的5年生存率降低结直肠癌手术后复发及转移的几率,能降低患者化疗引起的副反应。Objective ： To observe the clinical effects about Tianma granules inhibition of tumor recurrence in colorectal cancer. Methods ： Receiv- ing patients with colorectal cancer from March 2007 to March 2010 , a total of 120 patients were randomly divided into treatment and control group, giving the treated patients Tianma granules on the basis of conventional chemotherapy, the control group wasgiven conventional chemo- therapy, patients were followed up and documented tumorrecurrence and metastasis, immune parameters before and after treatment and side effects of treatment patients were poisoning using statistical methods to analyze data. Results： Follow-up after five years the incidence of retreatment group, overall survival, respectively, while the median survival （49.2% , 52.71%, 42.56 months） than the control group （67. 3%, 36.48%, 28.13 months）, and the difference was statistically significant （P 〈0.05）. A follow-up after the main course of treatment group immune parameters IgA, IgM, IgG, C3, respectively （0.81 ± 0.23,0.72 ± 0.24,8.13 ± 1.05,1.59 ± 0.21 ） g / L were superior to the control group （0.65 ± 0.15,0.60 -± 0.15,6.45 ± 0.89,0.95 ± 0.20） g/L, and the difference was statistically significant （ P 〈 0.05 ）. Treatment of diarrhea, neuritis, abnormal liver function, leukopenia, thrombocytopenia, were less than the number of cases in the control group, but the only significant differencediarrhea （P 〈 0.05）. Conclusion： Tianma granules can significantly improve the quality of life of patients with colorectal cancer after surgery, improve thefive-year survival rate of colorectal cancer after surgery reduced recurrence and me- tastasis probability of patients, and reduce the side effects caused by chemotherapy patients, further research and clinical worth applications.

关 键 词：天马颗粒剂 结直肠癌 复发 转移 

分 类 号：R735.34[医药卫生—肿瘤]