肝癌患者术前血清胸苷激酶1表达水平及其临床意义  

Preoperative expression level of serum thymidine kinase 1 in hepatocellular carcinoma patients and its clinical significance

作　　者：唐艳萍[1] 谢雨萱 蔡政民[1] 苏程琳[1] 谭晓玉[1] 张力图[1] 利基林 

机构地区：[1]广西医科大学附属肿瘤医院实验研究部,南宁市530021

出　　处：《广西医学》2016年第9期1219-1221,共3页Guangxi Medical Journal

基　　金：广西科学研究与技术开发计划(桂科攻1298003-2-8)

摘　　要：目的探讨肝细胞肝癌患者术前血清胸苷激酶1(TK1)表达水平及其临床意义。方法采用免疫印迹增强化学发光法检测125例肝细胞肝癌患者(肝癌组)、30例肝脏良性病变患者(肝脏良性病变组)和40例健康体检者(健康对照组)血清TK1水平。分析肝癌组患者TK1水平与临床病理特征的关系。结果肝癌组血清TK1水平和阳性表达率均明显高于肝脏良性病变组和健康对照组(P<0.05),而肝脏良性病变组与健康对照组比较,差异无统计学意义(P>0.05)。巴塞罗那临床肝癌分期为(B+C)期肝癌患者血清TK1水平高于(0+A)期肝癌患者(P<0.05)。结论检测血清TK1对肝癌的诊断具有一定的临床参考价值。Objective To investigate the preoperative expression level of serum thymidine kinase 1 （TK1） in patients with hepatocelhdar carcinoma（HCC） and its clinical significance. Methods The serum levels of TK1 of 125 patients with HCC （ HCC group） ,30 patients with liver benign lesions（ liver benign lesion group） and 40 normal individuals（ health control group） were detected by enhanced Western blot-chemiluminescence assay. The relationship of TK1 level with elinicopathological features was analyzed in HCC group. Results The serum level and positive expression rate of TK1 in the HCC group were significantly higher than those in the liver benign lesion group and health control group （P 〈 0. 05） ,but no significant different was found between liver benign lesion group and health control group （P 〉 0.05 ）. The serum level of TK1 in HCC patients with Barcelona Clinic Liver Cancer stage （ B ＋ C ） was higher than that in the patients with stage （0 ＋ A） （P 〈0.05）. Conclusion The detection of serum TK1 has a certain clinical reference value in the diagnosis of HCC.

关 键 词：肝细胞肝癌 血清胸苷激酶1 

分 类 号：R735.7[医药卫生—肿瘤]